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山口　雅利 ヤマグチ マサトシ

■所属部署名 理工学研究科　物質科学部門 ■電話番号
■職名 准教授 ■FAX番号
■住所 埼玉県さいたま市桜区下大久保255 ■メールアドレス yamagu＠mail.saitama-u.ac.jp
■ホームページURL

プロフィール

兼担研究科・学部

工学部　応用化学科

研究分野

生物化学、生物工学
キーワード：植物バイオテクノロジー , 二次細胞壁 , 代謝改変

学歴

出身大学院・研究科等
2001 , 東京大学 , 博士 , 理学系研究科 , 生物科学専攻 , 修了
1998 , 東京大学 , 修士 , 理学系研究科 , 生物科学専攻 , 修了
出身学校・専攻等(大学院を除く)
1996 , 東京理科大学 , 基礎工学部 , 生物工学科 , 卒業
取得学位
博士（理学） , 東京大学

受賞学術賞

2013 , 日本植物細胞分子生物学会奨励賞 , 「道管分化を制御する遺伝子発現転写ネットワークの解析」

研究職歴等

研究職歴
2022 , 埼玉大学　工学部応用化学科　准教授
2014 - 2022 , 埼玉大学　理工学研究科戦略的研究部門グリーン環境領域　准教授
2011 - 2015 , 科学技術振興機構さきがけ　研究員
2011 - 2013 , 埼玉大学　環境科学研究センター　准教授
2009 - 2011 , 奈良先端科学技術大学院大学　バイオサイエンス研究科　助教
2006 - 2009 , 理化学研究所　研究員
2003 - 2006 , 理化学研究所　基礎化学特別研究員
2002 - 2003 , 東京大学　リサーチアソシエイト
2000 - 2002 , 日本学術振興会特別研究員
留学歴
2015 - 2016 , カナダ　ブリティッシュコロンビア大学　訪問研究員

研究活動業績

研究業績(著書・発表論文等)

論文
Loss of peroxisomal NAD kinase 3 (NADK3) affects photorespiration metabolism in Arabidopsis
Journal of Plant Physiology,283:153950 2023
Suzuki S, Tanaka D, Miyagi A, Takahara K, Kono M, Chamurilege, Noguchi K, Ishikawa T, Nagano M, Yamaguchi M, Kawai-Yamada M

Loss of peroxisomal NAD kinase 3 (NADK3) affects photorespiration metabolism in Arabidopsis.
Journal of Plant Physiology,283:153950 2023
Suzuki S, Tanaka D, Miyagi A, Takahara K, Kono M, Chaomurilege, Noguchi K, Ishikawa T, Nagano M, Yamaguchi M, Kawai-Yamada M

Metabolic changes associated with dark-induced leaf senescence in Arabidopsis nadk2 mutants.
Plant Signaling Behavior,18:2215618 2023
Chaomurilege, Miyagi A, Ishikawa T, Yamaguchi M, Murayama H, Kawai-Yamada M

Heterologous expression of mtf and mtc genes of Pseudanabaena foetida var. intermedia is sufficient to produce 2-methylisoborneol in Escherichia coli.
Microbiology Spectrum,11:e02561-23 2023
Dayarathne K, Ishikawa T, Watanabe S, Ishikawa Y, Aikeranmu K, Kitagawa H, Komatsubara N, Yamaguchi M, Kawai-Yamada M

NAC domain transcription factors VNI2 and ATAF2 form protein complexes, and regulate leaf senescence.
Plant Directs,7:e529 2023
Nagahage ISP, Matsuda K, Miyashita K, Fujiwara S, Mannapperuma C, Yamada T, Sakamoto S, Ishikawa T, Nagano M, Ohtani M, Kato K, Uchimiya H, Mitsuda N, Kawai-Yamada M, Demura T, Yamaguchi M

Sphingolipids with 2-hydroxy fatty acids aid in plasma membrane nanodomain organization and oxidative burst
Plant Physiology,189:839–857 2022
Ukawa T, Banno F, Ishikawa T, Kasahara K, Nishina Y, Inoue R, Tsujii K, Yamaguchi M, Takahashi T, Fukao Y, Kawai-Yamada M, Nagano M

VNI2 effectively inhibits transcriptional activities of VND7 through a conserved sequence.
Plant Biotechnology,31:147–153 2022
Ailizati A, Nagahage ISP, Miyagi A, Ishikawa T, Kawai-Yamada M, Demura T, Yamaguchi M

Loss of chloroplast-localized NAD kinase causes ROS stress in Arabidopsis thaliana
Journal of Plant Research,136:97–106 2022
Chaomurilege, Zu Y, Miyagi A, Hashida SH, Ishikawa T, Yamaguchi M, Kawai-Yamada M

Metabolomic analysis of rice brittle culm mutants reveals each mutant- specific metabolic pattern in each organ
Metabolomics,18:95 2022
Miyagi A, Mori K, Ishikawa T, Ohkubo S, Adachi S, Yamaguchi M, Oikawa T, Kotake T, Kawai-Yamada M

Change in expression levels of NAD kinase-encoding genes in Flaveria Species.
Journal of Plant Physiology,265:153495 2021
Tanaka M, Ishikawa Y, Suzuki S, Ogawa T, Taniguchi YY, Miyagi A, Ishikawa T, Yamaguchi M, Munekage YN, Kawai-Yamada M

An Arabidopsis NAC domain transcriptional activator VND7 negatively regulates VNI2 expression.
Plant Biotechnology,38:415-420 2021
Ailizati A, Nagahage ISP, Miyagi A, Ishikawa T, Kawai-Yamada M, Demura T, Yamaguchi M

The NAD kinase Slr0400 functions as growth repressor in Synechocystis PCC 6803.
Plant Cell Physiology,62:668-677 2021
Ishikawa Y, Cassan C, Kadeer A, Yuasa K, Sato N, Sonoike K, Kaneko Y, Miyagi A, Takahashi H, Ishikawa T, Yamaguchi M, Nishiyama Y, Hihara Y, Gibon Y, Kawai-Yamada M

An Arabidopsis NAC domain transcription factor, ATAF2, promotes age-dependent and dark-induced leaf senescence.
Physiologia Plantarum,170:299-308 2020
Nagahage ISP, Sakamoto S, Nagano M, Ishikawa T, Kawai-Yamada M, Mitsuda N, Yamaguchi M

The Class II KNOX genes KNAT3 and KNAT7 work forperatively to influence secondary cell wall deposition and provide mechanical support to Arabidopsis stem.
Plant J,101:293-309 2020
Wang S, Yamaguchi M, Grienenberger E, Martone PT, Samuels AL, Mansfield S

Arabidopsis Group IIId ERF proteins positively regulate primary cell wall-type CESA genes.
Journal of Plant Research,132(1):117-129 2019
Saelim L, Akiyoshi N, Tan TT, Ihara A, Yamaguchi M, Hirano K, Matsuoka M, Demura T, Ohtani M

Affinity-based high-resolution analysis of DNA binding by VASCULAR-RELATED NAC-DOMAIN7 via fluorescence correlation spectorscopy .
Plant J,100:298-313 2019
Tamura T, Endo H, Suzuki A, Sato Y, Kato K, Ontani M, Yamaguchi M, Demura T

An NAC domain transcription factor ATAF2 acts as transcriptional activator or repressor dependent on promoter context.
Plant Biotechnology,35(3):285-289 2018
Nagahage ISP, Sakamoto S, Nagano M, Ishikawa T, Kawai-Yamada M, Mitsuda N, Yamaguchi M

Transcription Factors VND1-VND3 Contribute to Cotyledon Xylem Vessel Formation.
Plant Physiology,176:773-789 2018
Tan TT, Endo H, Sano R, Kurata T, Yamaguchi M, Ohtani M, Demura T

Heterologous expression and characterization of an Arabidopsis β-l-arabinopyranosidase and α-d-galactosidases acting on β-l-arabinopyranosyl residues.
Journal of Experimental Botany,68:4651-5661 2017
Imaizumi C, Tomatsu H, Kitazawa K, Yoshimi Y, Shibano S, Kikuchi K, Yamaguchi M, Kaneko S, Tsumuraya Y, Kotake T

Multiple classes of transcription factors regulate the expression of VASCULAR-RELATED NAC-DOMAIN7, a master switch of xylem vessel differentiation
Plant Cell Physiology,56(2):242-254 2015
Hitoshi Endo, Masatoshi Yamaguchi, Taizo Tamura, Yoshimi Nakano, Nobuyuki Nishikubo, Arata Yoneda, Ko Kato, Minoru Kubo, Shinya Kajita, Yoshihiro Katayama, Misato Ohtani, Taku Demura

Arabidopsis NAC domain proteins VND-INTERACTING1 and ANAC103 interacts with multiple NAC domain proteins.
Plant Biotechnology,32(2):119–123 2015
Masatoshi Yamaguchi, Isura SP Nagahage, Misato Ohtani, Toshiki Ishikawa, Hirofumi Uchimiya, Maki Kawai-Yamada, Taku Demura

NAC-MYB-based transcriptional regulation of secondary cell wall biosynthesis in land plants
Frontiers in Plant Science,6:288 2015
Yoshimi Nakano, Masatoshi Yamaguchi, Hitoshi Endo, Nur Ardiyana Rejab, Misato Ohtani

Contribution of NAC transcription factors to plant adaptation to land
Science,343:1505-1508 2014
Bo Xu, Misato Ohtani, Masatoshi Yamaguchi, Kiminori Toyooka, Mayumi Wakazaki, Mayuko Sato, Minoru Kubo, Yoshimi Nakano, Ryosuke Sano, Yuji Hiwatashi, Takashi Murata, Tetsuya Kurata, Arata Yoneda, Ko Kato, Mitsuyasu Hasebe, Taku Demura

二次細胞壁形成の時空間的制御
生物の科学　遺伝,第６６巻(1号):40-46 2012
大谷美沙都、山口雅利、出村拓

植物二次細胞壁形成の転写制御機構
化学と生物,第４９巻(11号):770-777 2011
山口雅利、大谷美沙都、出村拓

VASCULAR-RELATED NAC-DOMAIN7 directly regulates the expression of a broad range of genes for xylem vessel formation.
Plant Journal,66:579-590 2011
Masatoshi Yamaguchi, Nobutaka Mitsuda, Misato Ohtani, Masaru Ohme-Takagi, Ko Kato, Taku Demura
電子ジャーナル PubMed

A NAC domain protein family contributing to regulation of wood formation in poplar.
Plant Journal,67:499-512 2011
Misato Ohtani, Nobuyuki Nishikubo, Bo Xu, Masatoshi Yamaguchi, Nobutaka Mitsuda, Nadia Gou , Fusun Shi, Masaru Ohme-Takagi, Taku Demura
電子ジャーナル PubMed

VND-INTERACTING2, a NAC domain transcription factor, negatively regulates xylem vessel formation in Arabidopsis.
Plant Cell,22:1249-1263 2010
Masatoshi Yamaguchi, Misato Ohtani, Nobutaka Mitsuda, Minoru Kubo, Masaru Ohme-Takagi, Hiroo Fukuda, Taku Demura
電子ジャーナル PubMed

Transcriptional regulation of secondary wall formation controlled by NAC domain proteins.
Plant Biotechnology,27:237-242 2010
Masatoshi Yamaguchi, Taku Demura
電子ジャーナル

VASCULAR-RELATED NAC-DOMAIN6 and VASCULAR-RELATED NAC-DOMAIN7 effectively induce transdifferentiation into xylem vessel elements under control of an induction system.
Plant Physiology,153:906-914 2010
Masatoshi Yamaguchi, Nadia Gou , Hisako Igarashi, Misato Ohtani, Yoshimi Nakano, Jennifer C. Mortimer, Nobuyuki Nishikubo, Minoru Kubo, Yoshihiro Katayama, Koichi Kakegawa, Paul Dupree, Taku Demura
電子ジャーナル PubMed

VASCULAR-RELATED NAC-DOMAIN7 is involved in the differentiation of all types of xylem vessels in Arabidopsis roots and shoots.
Plant Journal,55:652-664 2008
Masatoshi Yamaguchi, Minoru Kubo, Hiroo Fukuda, Taku Demura
電子ジャーナル PubMed

Control of cell division and transcription by cyclin-dependent kinase-activating kinase in plants.
Plant Cell Physiology,46:1437-1442 2005
ISBN:DOI: 10.1093/pcp/pci170
Masaaki Umeda, Akie Shimotohno, Masatoshi Yamaguchi
PubMed

Transcription switches for protoxylem and metaxylem vessel formation.
Genes & Development,19:1855-1860 2005
Minoru Kubo, Makiko Udagawa, Nobuyuki Nishikubo, Gorou Horiguchi, Masatoshi Yamaguchi, Jun Ito, Tetsuro Mimura, Hiroo Fukuda, Taku Demura
電子ジャーナル PubMed

Control of in vitro organogenesis by cyclin-dependent kinase activities in plants.
Proceedings of the National Academy of Science of the USA,100:8019-8023 2003
ISBN:DOI: 10.1073/pnas.1332637100
Masatoshi Yamaguchi, Hisashi Kato, Shigeo Yoshida, Saburo Yamamura, Hirofumi Uchimiya, Masaaki Umeda
PubMed

Activation of CDK-activating kinase is dependent on interaction with H-type cyclins in plants.
Plant Journal,24:11-20 2000
Masatoshi Yamaguchi, Tanja Fabian, Margret Sauter, Rishikesh P. Bhalerao, Jarmo Schrader, G ran Sandberg, Masaaki Umeda, Hirofumi Uchimiya
電子ジャーナル PubMed リポジトリ

A rice homolog of Cdk7/MO15 phosphorylates both cyclin-dependent kinases and the carboxy-terminal domain of RNA polymerase II.
Plant Journal,16(5):613-619 1998
Masatoshi Yamaguchi, Masaaki Umeda, Hirofumi Uchimiya
電子ジャーナル PubMed

学会発表
Stability of VNI2 protein is regulated by an interacting protein
The Canadian Society of Plant Biologists Eastern Regional Meeting 201511
Masatoshi Yamaguchi, Junko Kitagawa, Hirofumi Uchimiya, Maki Kawai-Yamada, Taku Demura

A transcriptional repressor, VNI2, modulates secondary cell wall content
11th International Congress of Plant Molecular Biology 2015 201510
Masatoshi Yamaguchi, Shingo Sakamoto, Maki Kawai-Yamada, Taku Demura, Hirofumi Uchimiya, Nobutaka Mitsuda

NAC domain transcription factors interacting why VND7, a key regulator of xylem vessel differentiation
Botany 2015 Science and Plants for People,Botany 2015 Abstracts:373 201507
Masatoshi Yamaguchi, Nagahage Isura, Misato Ohtani, Toshiki Ishikawa, Hirofumi Uchimiya, Hiroo Fukuda, Maki Kawai-Yamada, Taku Demura

Stability of VNI2 protein is regulated by RING finger proteins
The 26th International Conference on Arabidopsis Research,Abstract book ICAR 2015:120 201507
Masatoshi Yamaguchi, Junko Kitagawa, Kohei Matsuda, Hirofumi Uchimiya, Maki Kawai-Yamada, Taku Demura

RING finger proteins regulate protein stability of VNI2
The 5th Symposium on International Collaborative Laboratories, Front Lines of Plant Cell Wall Research 201503
Masatoshi Yamaguchi

BRITTLE CULM 4 mutant decreases in secondary cell wall formation in rice
5th International Conference Plant Cell Wall Biology 201407
Masatoshi Yamaguchi, Ami Sato, Mami Yoshimura, Tetsuya Kurata, Maki Kawai-Yamada, Shinji Kawasaki, Yoichi Tsumuraya, Toshiki Kotake

研究費

科学研究費補助金(研究代表者)
2018-2022 , 様々なNACドメイン転写因子と複合体を形成するVNI2の多面的な生物学的役割 , 基盤研究(C)
2015-2018 , NACドメイン転写因子ヘテロ複合体の生物学的役割 , 基盤研究(C)
2013-2014 , NAC転写因子複合体の作用機構と生物学的な役割 , 若手研究（B）
科学研究費補助金(研究分担者)
2023-2026 , 機能性を高めるグルコマンナン高アセチル化の分子メカニズム , 基盤研究(B)
2019-2021 , 超高感度光干渉法による多元的植物の環境汚染ストレス・活性の無侵襲極短時間モニタ法 , 基盤研究(B)

研究諸活動

学術専門雑誌等編集
2022- , Plant Biotechnology, Vice-Editor-in-Chief
2017-2020 , Plant Cell Physiology, Advisory Editorial Board
2012-2020 , Plant Biotechnology, Associate Editor

教育活動実績

授業等

前期 , 生物学基礎
前期 , 応用化学実験III
後期 , 工学入門セミナー
前期 , 生物代謝工学特論

社会活動実績

社会活動等

学外審議会・委員会
2019- , さいたま市環境影響評価技術審議会
2018-2022 , 埼玉県環境影響評価技術審議会