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MATSUSHITA Takahiko

Faculty: Graduate School of Science and Engineering TEL:
Position: Assistant Professor ■FAX:
Address: 255 Shimo-Okubo, Sakura-ku, Saitama City, Saitama 338-8570, JAPAN ■Mail Address: takahiko@fms.saitama-u.ac.jp
■Web site: http://md.fms.saitama-u.ac.jp

Profile

Assigned Class

Faculty of Engineering
Advanced Institute of Innovative Technology

Research Field

Synthetic chemistry
Polymer chemistry
Biochemistry
Analytical chemistry
keyword:Carbohydrate , Peptide , Glycopeptide , Glycosyltransferase , Antibody , Synthetic polymer , Multivalent polymer , Antibiotics , Lectin

Academic Societies

Academic Societies
The Japanese Society of Carbohydrate Research , Regular member
The Chemical Society of Japan , Regular member
The Society of Polymer Science, Japan , Regular member

Academic Background

Graduate School
Hokkaido University , (Doctor later , Graduate School of Science , Division of Biological Sciences) , 2005(Accomplished credits for doctoral program)
Hokkaido University , (Doctor prophase , Graduate School of Science , Division of Biological Sciences) , 2002(Completed)
College
Hokkaido University , (Division of Biological Sciences , School of Science) , 2000(Graduated)
Degree
Ph.D. in science , Hokkaido University

Awards

2011 , Award for Encouragement of Research in Polymer Science , Chemical and Enzymatic Synthesis of MUC1 Glycopeptide Library

Research Career

Research Career
2015 , Saitama university, Assistant professor
2013 - 2015 , Research Scholar at Department of Chemistry, Wayne State University, USA
2008 - 2013 , Specially Appointed Assistant Professor at Faculty of Advanced Life Science, Hokkaido University, Japan
2005 - 2008 , Research Associate at National Institute of Advanced Industrial Science and Technology

Research

Books, Articles, etc.

Books
Methods in Enzymology vol.478 " Novel Synthesis of Functional Mucin Glycopeptides Containing Both N- and O-glycans."
Elsevier Inc.:485-502 201011
Takahiko Matsushita, Shin-Ichiro Nishimura

Articles
Preparation of a water-soluble polymer having pheophorbide a side chains using glycopolymer assembly
,Tetrahedron Letters,134:154963 2024
Koji Matsuoka, Jyuichi Nakada, Masataka Nakazato, Takahiko Matsushita, Tetsuo Koyama, Ken Hatano

Preparation of fluorogenic glycopolymers having mannose moieties that can be used for determining the affinity of lectins by means of intermolecular FRET
,Journal of Molecular Structure,1306:137896 2024
Kota Miyairi, Takahiko Matsushita, Tetsuo Koyama, Ken Hatano, Koji Matsuoka

pH-Dependent proteolytic activity of histidine-pendant polyacrylamides
,European Polymer Journal,209:112898 2024
Shinzo Omiya, Hinako Yamochi, Tetsuo Koyama, Ken Hatano, Koji Matsuoka, Takahiko Matsushita

Proteolytic polymer: polyacrylamides functionalized with amino acids cleave bovine and human serum albumins
,Bioorganic & Medicinal Chemistry,92:117422 2023
Takahiko Matsushita, Hinako Yamochi, Shinzo Omiya, Tetsuo Koyama, Ken Hatano, Koji Matsuoka

Synthetic assembly of a series of glycopolymers having sialyl α2-3 lactose moieties connected with longer spacer arms
,Bioorganic & Medicinal Chemistry,81:117209 2023
Ryota Adachi, Takahiko Matsushita, Tetsuo Koyama, Ken Hatano, Koji Matsuoka

Use of a longer aglycon moiety bearing sialyl α(2→3) lactoside on the glycopolymer for lectin evaluation
,Polymers,15(4):998 2023
Ryota Adachi, Takahiko Matsushita, Tetsuo Koyama, Ken Hatano, Koji Matsuoka

Synthesis of 4-O-(4-Amino-2-deoxy-β-D-xylopyranosyl)paromomycin and 4-S-(4-Amino-2-deoxy-β-D-xylopyranosyl)-4-deoxy-4’-thio-paromomycin and Evaluation of their Antiribosomal and Antibacterial Activity
,Tetrahedron,135:133330 2023
Rukshana Mohamad-Ramshan, Chennaiah Ande, Takahiko Matsushita, Klara Haldimann, Andrea Vasella, Sven N. Hobbie, David Crich

N-glycosylated VHH Antibodies
,Trends in Glycoscience and Glycotechnology,35(207):E87 2023
Takahiko Matsushita

Preparation of a Water-Soluble Glycopolymer Bearing Porphyrin Skeletons and Its Biological Properties
,ACS Omega,8(40):37451–37460 2023
Yoshihiro Ishimaru, Tomohide Moteki, Miho Suzuki, Tetsuo Koyama, Takahiko Matsushita, Ken Hatano, Koji Matsuoka

Preparation of N-Linked-Type GlcNAc Monomers for Glycopolymers and Binding Specificity for Lectin
,ACS Omega,8(40):37329–37340 2023
Takahiko Matsushita, Momoka Nozaki, Mio Sunaga, Tetsuo Koyama, Ken Hatano, Koji Matsuoka

Chemical modification of CNN 1. Complete protection of CNN
,Tetrahedron Letters,103:153986 2022
Koji Matsuoka, Daiki Endo, Ryota Adachi, Tetsuo Koyama, Takahiko Matsushita, Ken Hatano

Systematic Synthesis of a Series of Glycopolymers having N-acetyl-D-Glucosamine Moieties that can be Used for Evaluations of Lectin-Carbohydrate Interactions
,European Polymer Journal,168:111101 2022
Koji Matsuoka, Masaki Nakagawa, Tetsuo Koyama, Takahiko Matsushita, Ken Hatano

Dendritic maleimide-thiol adducts carrying pendant glycosides as high-affinity ligands
,Bioorganic Chemistry,128:106061 2022
Takahiko Matsushita, Naomichi Toda, Tetsuo Koyama, Ken Hatano, Koji Matsuoka

Preparation of lauryl thioglycoside of N-glycolylneuraminic acid (Neu5Gc) as a useful glycosyl donor for assembly of an oligosaccharide containing Neu5Gc
,Tetrahedron Letters,83(26):153403 202110
Jianhong Zhang,Tetsuo Koyama, Takahiko Matsushita, KenHatano, Koji Matsuoka

Preparation of glycopolymers having sialyl α2 → 3 lactose moieties as the potent inhibitors for mumps virus
,Bioorganic & Medicinal Chemistry Letters,52:128389 202110
Koji Matsuoka, Takayuki Kaneshima, Ryota Adachi, Jiei Sasaki, Takao Hashiguchi, Tetsuo Koyama, Takahiko Matsushita, Ken Hatano

Synthesis and Antibacterial Activity of Propylamycin Derivatives Functionalized at the 5′′- and Other Positions with a View to Overcoming Resistance Due to Aminoglycoside Modifying Enzymes
,ACS Infectious Diseases,7(8):2413–2424 202106
Dimitrijs Lubriks, Rimants Zogota, Vikram A. Sarpe, Takahiko Matsushita, Girish C. Sati, Klara Haldimann, Marina Gysin, Erik C. Böttger, Andrea Vasella, Edgars Suna, David Crich

Fluorogenic glycopolymers available for determining the affinity of lectins by intermolecular FRET
,Bioorganic & Medicinal Chemistry Letters,30(8):127024 2020
Koji Matsuoka, Yuya Suzuki, Tetsuo Koyama, Takahiko Matsushita, Ken Hatano

Impaired O-glycosylation at consecutive threonine TTX motifs in mucins generates conformationally restricted cancer neoepitopes
,Biochemistry,59(12):1221-1241 2020
Shun Hayakawa,Takahiko Matsushita, Yasuhiro Yokoi, Hajime Wakui, Fayna Garucia-Martin, Hiroshi Hinou, Koji Matsuoka, Kazuhiro Nouso, Toshiya Kamiyama, Akinobu Taketomi, Shin-Ichiro Nishimura

Verification of suitable ratio of carbohydrate residues in a glycopolymer having GlcNAc moieties for determining the affinity for wheat germ agglutinin
,Journal of Molecular Structure,1217:128404 2020
Koji Matsuoka, Shohei Yamashita, Tetsuo Koyama, Takahiko Matsushita, Ken Hatano

Stereospecific synthesis of methyl 2-amino-2,4-dideoxy-6S-deuterio-α-D-xylo-hexopyranoside and methyl 2-amino-2,4-dideoxy-6S-deuterio-4-propylα-D-glucopyranoside: Side chain conformation of the novel aminoglycoside antibiotic propylamycin
,Carbohydrate Research,491:107984 2020
Michael G.Pirrone, Takahiko Matsushita, AndreaVasella, David Crich

Neuraminidase-triggered activation of prodrug-type substrate of 4-nitroaniline
,Bioorganic & Medicinal Chemistry Letters,30(2):126883 2020
Takahiko Matsushita, Monique Nami Danyel, Tetsuo Koyama, Ken Hatano, Koji Matsuoka

Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens
,Journal of the American Chemical Society,141(12):5051-5061 2019
Matsushita T, Sati GC, Kondasinghe N, Pirrone MG, Kato T, Waduge P, Kumar HS, Sanchon AC, Dobosz-Bartoszek M, Shcherbakov D, Juhas M, Hobbie SN, Schrepfer T, Chow CS, Polikanov YS, Schacht J, Vasella A, Böttger EC, Crich D

Synthetic construction of sugar-amino acid hybrid polymers involving globotriaose or lactose and evaluation of their biological activities against Shiga toxins produced by Escherichia coli O157:H7
,Bioorganic & Medicinal Chemistry,26(22):5792-5803 2018
Koji Matsuoka, Kiyotaka Nishikaw, Yusuke Goshu, Tetsuo Koyama, Ken Hatano, Takahiko Matsushita, Miho Watanabe-Takahashi, Yasuhiro Natori, Daiyo Terunuma

A constraint scaffold enhances affinity of a bivalent N-acetylglucosamine ligand against wheat germ agglutinin
,Bioorganic & Medicinal Chemistry Letters,28(10):1704-1707 2018
Takahiko Matsushita, Koji Tsuchibuchi, Tetsuo Koyama, Ken Hatano, Koji Matsuoka

Preparation of Functional Monomers as Precursors of Bioprobes from a Common Styrene Derivative and Polymer Synthesis
,Molecules,23(11):2875 2018
Riho Hayama, Tetsuo Koyama, Takahiko Matsushita, Ken Hatano, Koji Matsuoka

Iodoacetyl-functionalized pullulan: A supplemental enhancer for single-domain antibody–polyclonal antibody sandwich enzyme-linked immunosorbent assay for detection of survivin
,Bioorganic & Medicinal Chemistry Letters,27(21):4844-4848 2017
Takahiko Matsushita, Hidenao Arai, Tetsuo Koyama, Ken Hatano, Naoto Nemoto, Koji Matsuoka

The Quest for Anticancer Vaccines: Deciphering the Fine-Epitope Specificity of Cancer-Related Monoclonal Antibodies by Combining Microarray Screening and Saturation Transfer Difference NMR
,Journal of the American Chemical Society,137(39):12438-12441 2015
Helena Coelho, Takahiko Matsushita, Gerard Artigas, Hiroshi Hinou, F. Javier Cañada, Richard Lo-Man, Claude Leclerc, Eurico J. Cabrita, Jesús Jiménez-Barbero, Shin-Ichiro Nishimura, Fayna Garcia-Martín, Filipa Marcelo

Influence of 4′-O-Glycoside Constitution and Configuration on Ribosomal Selectivity of Paromomycin
,Journal of the American Chemical Society,137(24):7706-7717 2015
Takahiko Matsushita, Weiwei Chen, Reda Juskeviciene, Youjin Teo, Dimitri Shcherbakov, Andrea Vasella, Erik C. Böttger, David Crich

Fluorine-Decoupled Carbon Spectroscopy for the Determination of Configuration at Fully Substituted, Trifluoromethyl- and Perfluoroalkyl-Bearing Carbons: Comparison with 19F–1H Heteronuclear Overhauser Effect Spectroscopy
,The Journal of Organic Chemistry,80(3):1754-1763 2015
Appi Reddy Mandhapati, Takayuki Kato, Takahiko Matsushita, Bashar Ksebati, Andrea Vasella, Erik C. Böttger, David Crich

Fast epitope mapping for the anti-MUC1 monoclonal antibody by combining one-bead-one-glycopeptide library and microarray platform
,Chemistry - A European Journal,20(48):15891-15902 2014
Fayna Garcia-Martin, Takahiko Matsushita, Hiroshi Hinou, Shin-Ichiro Nishimura

Delineating Binding Modes of Gal/GalNAc and Structural Elements of the Molecular Recognition of Tumor-Associated Mucin Glycopeptides by the Human Macrophage Galactose-Type Lectin
,Chemistry - A European Journal,20(49):16147-16155 2014
Marcelo, F., Garcia-Martin, F., Matsushita, T., Sardinha, J., Coelho, H., Oude-Vrielink, A., Koller, C., Andre, S., Cabrita, E. J., Gabius, H.-J., Nishimura, S.-I., Jimenez-Barbero, J., and Canada, F. J.

Synthesis, antiribosomal and antibacterial activity of 4′-O-glycopyranosyl paromomycin aminoglycoside antibiotics
,MedChemComm,5:1179-1187 2014
Weiwei Chen, Takahiko Matsushita, Dimitri Shcherbakov, Heithem Boukari, Andrea Vasella, Erik C. Böttger, David Crich

A straightforward protocol for the preparation of high performance microarray displaying synthetic MUC1 glycopeptides
,Biochimica Et Biophysica Acta-general Subjects,1840(3):1105-1116 2014
Takahiko Matsushita, Wataru Takada, Kota Igarashi, Kentaro Naruchi, Risho Miyoshi, Fayna Garcia-Martin, Maho Amano, Hiroshi Hinou, Shin-Ichiro Nishimura

Site-specific Conformational Alteration Induced by Sialylation of MUC1 Tandem Repeating Glycopeptides at An Epitope Region for Anti-KL-6 Monoclonal Antibody
,Biochemistry,52(2):402-414 2013
Takahiko Matsushita, Naoki Ohyabu, Naoki Fujitani, Kentaro Naruchi, Hiroki Shimizu, Hiroshi Hinou, Shin-Ichiro Nishimura

A Novel Approach for the Parallel Synthesis of Glycopeptides by Combining Solid-Phase Peptide Synthesis and Dendrimer-supported Enzymatic Modifications
,Polymer Journal,45(8):854-862 2013
Takahiko Matsushita, Seiji Handa, Kentaro Naruchi, Fayna Garcia-Martin, Hiroshi Hinou, Shin-Ichiro Nishimura

Microwave-Assisted Solid-Phase Synthesis of Antifreeze Glycopeptides
,Chemistry - A European Journal,19(12):3913-3920 2013
Ryuko Izumi, Takahiko Matsushita, Naoki Fujitani, Kentaro Naruchi, Hiroki Shimizu, Sakae Tsuda, Hiroshi Hinou, Shin-Ichiro Nishimura

Macrocyclic Mechanism-Based Inhibitor for Neuraminidases
,Chemistry - A European Journal,19(4):1364-1372 2013
Hirokazu Kai, Hiroshi Hinou, Kentaro Naruchi, Takahiko Matsushita, Shin-Ichiro Nishimura

An Efficient Protocol for the Solid-Phase Synthesis of Glycopeptides under Microwave Irradiation
,Organic & Biomolecular Chemistry,10(8):1612-1617 2012
Fayna Garcia-Martin, Hiroshi Hinou, Takahiko Matsushita, Syun Hayakawa, Shin-Ichiro Nishimura

An Efficient Approach for the Characterization of Mucin-Type Glycopeptides: The Effect of O-Glycosylation on the Conformation of Synthetic Mucin Peptides
,Chemistry - A European Journal,17(8):2393-2404 2011
Ryo Hashimoto, Naoki Fujitani, Yasuhiro Takegawa, Masaki Kurogochi, Takahiko Matsushita, Kentaro Naruchi, Naoki Ohyabu, Hiroshi Hinou, Xiao Dong Gao, Naomi Manri, Hiroyuki Satake, Akihito Kaneko, Takeshi Sakamoto, Shin-Ichiro Nishimura

Chemical Synthesis, Folding, and Structural Insights into O-Fucosylated Epidermal Growth Factor-like Repeat 12 of Mouse Notch-1 Receptor
,Journal of the American Chemical Society,132(42):14857-14865 2010
Kazumi Hiruma-Shimizu, Kensaku Hosoguchi, Yan Liu, Naoki Fujitani, Takashi Ohta, Hiroshi Hinou, Takahiko Matsushita, Hiroki Shimizu, Ten Feizi, Shin-Ichiro Nishimura

Sialic Acid-focused Quantitative Mouse Serum Glycoproteomics by Multiple Reaction Monitoring Assay
,Molecular & Cellular Proteomics,9(11):2354-2368 2010
Masaki Kurogochi, Takahiko Matsushita, Maho Amano, Jun-ichi Furukawa, Yasuro Shinohara, Masato Aoshima, Shin-Ichiro Nishimura

Artificial Golgi Apparatus: Globular Protein-like Dendrimer Facilitates Fully Automated Enzymatic Glycan Synthesis
,Journal of the American Chemical Society,132(46):16651-16656 2010
Takahiko Matsushita, Izuru Nagashima, Masataka Fumoto, Takashi Ohta, Kuriko Yamada, Hiroki Shimizu, Hiroshi Hinou, Kentaro Naruchi, Takaomi Ito, Hirosato Kondo, Shin-Ichiro Nishimura

Unexpected Tolerance of Glycosylation by UDP-GalNAc:Polypeptide -N-Acetylgalactosaminyltransferase Revealed by Electron Capture Dissociation Mass Spectrometry: Carbohydrate as Potential Protective Groups
,Biochemistry,49(28):5929-5941 2010
Yayoi Yoshimura, Takahiko Matsushita, Naoki Fujitani, Yasuhiro Takegawa, Haruhiko Fujihara, Kentarou Naruchi, Xiao-Dong Gao, Naomi Manri, Takeshi Sakamoto, Kentaro Kato, Hiroshi Hinou, Shin-Ichiro Nishimura

Functional Neoglycopeptides: Synthesis and Characterization of New Class MUC1 Glycoprotein Models Having Core 2-based O-Glycan and Complex-type N-Glycan Chains
,Biochemistry,48(46):11117-11133 2009
Matsushita, T., Sadamoto, R., Ohyabu, N., Nakata, H., Fumoto, M., Fujitani, N., Takegawa, Y., Sakamoto, T., Kurogochi, M., Hinou, H., Shimizu, H., Ito, T., Naruchi, K., Togame, H., Takemoto, H., Kondo, H., Nishimura, S.-I.

An Essential Epitope of Anti MUC1 Monoclonal Antibody KL-6 Revealed by Focused Glycopeptide Library
,Journal of the American Chemical Society,131(47):17102-17109 2009
Naoki Ohyabu, Hiroshi Hinou, Takahiko Matsushita, Ryukou Izumi, Hiroki Shimizu, Keiko Kawamoto, Yoshito Numata, Hiroko Togame, Hiroshi Takemoto, Hirosato Kondo, Shin-Ichiro Nishimura

Chemical and Enzymatic Synthesis of Neoglycolipids in the Presence of Cyclodextrins
,Tetrahedron Letters,49(21):3413-3418 2008
Izuru Nagashima, Hiroki Shimizu, Takahiko Matsushita, Shin-Ichiro Nishimura

Construction of Highly Glycosylated Mucin-Type Glycopeptides Based on Microwave-Assisted Solid-Phase Syntheses and Enzymatic Modifications
,The Journal of Organic Chemistry,71(8):3051-3063 2006
Takahiko Matsushita, Hiroshi Hinou, Masataka Fumoto, Masaki Kurogochi, Naoki Fujitani, Hiroki Shimizu, Shin-Ichiro Nishimura

Construction and Structural Characterization of Versatile Lactosaminoglycan-related Compound Library for the Synthesis of Complex Glycopeptides and Sphingoglycolipids
,The Journal of Organic Chemistry,71(26):9609-9621 2006
Kentarou Naruchi, Tomoki Hamamoto, Masaki Kurogochi, Hiroshi Hinou, Hiroki

High-throughput protein glycomics: Combined Use of Chemoselective Glycoblotting and MALDI-TOF/TOF Mass Spectrometry
,Angewandte Chemie International Edition,44(1):91-96 2005
Shin-Ichiro Nishimura, Kenichi Niikura, Masaki Kurogochi, Takahiko Matsushita, Masataka Fumoto, Hiroshi Hinou, Ryousuke Kamitani, Hiroaki Nakagawa, Kisaburo Deguchi, Nobuaki Miura, Kenji Monde, Hirosato Kondo

Rapid Microwave-Assisted Solid-Phase Glycopeptide Synthesis
,Organic Letters,7(5):877-880 2005
Takahiko Matsushita, Hiroshi Hinou, Masaki Kurogochi, Hiroki Shimizu, Shin-Ichiro Nishimura

Molecular Transporter Between Polymer Platforms: Highly Efficient Chemoenzymatic Glycopeptide Synthesis by the Combined Use of Solid-Phase andWater-Soluble Polymer Supports
,Angewandte Chemie International Edition,44(17):2534-2537 2005
Masataka Fumoto, Hiroshi Hinou, Takahiko Matsushita, Masaki Kurogochi, Takashi Ohta, Takaomi Ito, Kuriko Yamada, Akio Takimoto, Hirosato Kondo, Toshiyuki Inazu, Shin-Ichiro Nishimura

Post-Translational Modification of Proteins: Facile and Efficient Procedure for the Identificationof O-Glycosylation Sites by MALDI-LIFT-TOF/TOF Mass Spectrometry
,Angewandte Chemie International Edition,43(31):4071-4075 2004
Masaki Kurogochi, Takahiko Matsushita, Shin-Ichiro Nishimura

Presentation
Nanobody-Pullulan Conjugates for Enzyme-linked Immunosorbent Assay
Institut Kimia Malaysia (IKM), Himpunan Kimia Indonesia (HKI),International Congress on Pure & Applied Chemistry (ICPAC) Bali 2023:BCM06 202309
Takahiko Matsushita, Hidenao Arai, Tetsuo Koyama, Ken Hatano, Naoto Nemoto, Koji Matsuoka

A series of glycopolymers having N-acetyl-D-glucosamine moieties that can be used for evaluations of lectin—carbohydrate interactions
Asia Chem Corporation (ACC),International Congress on Pure & Applied Chemistry (ICPAC Kota Kinabalu 2022) (Kota Kinabalu, Malaysia), November 22-27:IGS 02 ( p.72) 202211
Koji Matsuoka, Masaki Nakagawa, Tetsuo Koyama, Takahiko Matsushita, Ken Hatano

Maleimide-functionalized Carbosilane Dendrimers as Multivalent Platforms
Asia Chem Corporation (ACC),International Congress on Pure & Applied Chemistry (ICPAC Kota Kinabalu 2022) (Kota Kinabalu, Malaysia), November 22-27:IGS47 (p.117) 202211
Takahiko Matsushita, Naomichi Toda, Tetsuo Koyama, Ken Hatano, Koji Matsuoka

Bivalent N-Acetylglucosamine Glycosides: Effect of Scaffold Constraint on Lectin-Carbohydrate Interaction
Institut Kimia Malaysia,International Congress on Pure & Applied Chemistry Langkawi (ICPAC Langkawi) 2018, Oct 30 - Nov 2, 2018, OBC-25:100 201810
T. Matsushita, K. Tsuchibuchi, T. Koyama, K. Hatano, K. Matsuoka