Keywords
Profile
OTSUKA Yuichi
■Faculty: | Department of Biochemistry and Molecular Biology, Graduate School of Science and Engineering | ■TEL: | 81-70-8819-4666 | |
■Position: | Associate Professor | ■FAX: | ||
■Address: | 255 Shimo-Okubo, Sakura-ku, Saitama City, Saitama 338-8570, JAPAN | ■Mail Address: | otsukay@mail.saitama-u.ac.jp | |
■Web site: |
Profile
Assigned Class
- Department of Biochemistry and Molecular Biology, Faculty of Science
Research Field
- Molecular Microbiology
Academic Societies
- Academic Societies
- American Society for Microbiology
- THe Molecular Biology Society of Japan
- Japanese Society for Bacteriology
Academic Background
- Graduate School
- Osaka University , (Doctor later , Department of Biological Sciences , Graduate School of Science) , 2003(Completed)
- Osaka University , (Doctor prophase , Department of Biological Sciences , Graduate School of Science) , 2000(Completed)
- College
- Osaka University , (Department of Biological Sciences , Faculty of Science) , 1998(Graduated)
- Degree
- Doctor of Science , Osaka University
Research Career
- Research Career
- 2018 , Saitama University, Department of Biochemistry and Molecular Biology, Associate Professor
- 2014 - 2018 , Dokkyo Medical University, School of Medicine, Assistant Professor
- 2009 - 2014 , Osaka University, Faculty of Science, Department of Biological Sciences, Assistant Professor
- 2004 - 2009 , The Ohio State University Postdoctoral Fellow
Research
Books, Articles, etc.
- Books
-
Endoribonucleases of the toxin-antitoxin systems induce abortive infection’ in “RNA Damage and Repair”
Springer Nature:Pages 3-26 202107
ISBN:978-3-030-76570-5
Yuichi Otsuka -
Approaches for studying PMR1 endonuclease-mediated mRNA decay
Academic Press, USA:241-263 2008
Otsuka Y, and Schoenberg DR - Articles
-
Phage single-stranded DNA-binding protein or host DNA damage triggers the activation of the AbpAB phage defense system
,mSphere,8(6):e0037223 2023
Takaomi Sasaki, Saya Takita, Takashi Fujishiro, Yunosuke Shintani, Satoki Nojiri, Ryota Yasui, Tetsuro Yonesaki, Yuichi Otsuka -
Manipulating interactions between T4 phage long tail fibers and Escherichia coli receptors.
,Appl. Environ. Microbiol. ,87(13):e00423-21 2021
Akiyo Suga, Marina Kawaguchi, Tetsuro Yonesaki, Yuichi Otsuka -
The hokW-sokW locus encodes a type I toxin–antitoxin system that facilitates the release of lysogenic Sp5 phage in enterohemorrhagic Escherichia coli O157.
,Toxins (Basel),13(11):796 2021
Kosuke Takada, Kotone Hama, Takaomi Sasaki, Yuichi Otsuka -
A short peptide derived from the ZorO toxin functions as an effective antimicrobial.
,Toxins,11(7):392; DOI:10.3390/toxins11070392 2019
Otsuka Y, Ishikawa T, Takahashi C, and Masuda M. -
RnlB antitoxin of the Escherichia coli RnlA-RnlB toxin–antitoxin module requires RNase HI for inhibition of RnlA toxin activity
,Toxins,9(1):29 2017
Naka K, Qi D, Yonesaki T, and Otsuka Y -
Characterization of the interactions between Escherichia coli receptors, LPS and OmpC, and bacteriophage T4 long tail fibers
,Microbiologyopen,5(6):1003-1015 2016
Washizaki A, Yonesaki T, and Otsuka Y -
Structural insights into the inhibition mechanism of bacterial toxin LsoA by bacteriophage antitoxin Dmd
,Mol Microbiol,101(5):757-769 2016
Wan H, Otsuka Y, Gao ZQ, Wei Y, Chen Z, Masuda M, Yonesaki T, Zhang H, and Dong YH -
Prokaryotic toxin–antitoxin systems: novel regulations of the toxins
,Curr Genet,62(2):379-382 2016
Otsuka Y, and Schoenberg DR -
An ADP-ribosyltransferase Alt of bacteriophage T4 negatively regulates the Escherichia coli MazF toxin of a toxin–antitoxin module
,Mol Microbiol,99(1):188-198 2016
Alawneh AM, Qi D, Yonesaki T, and Otsuka Y -
Rapid degradation of host mRNAs by stimulation of RNase E activity by Srd of bacteriophage T4
,Genetics,201(3):977-987 2015
Qi D, Alawneh AM, Yonesaki T, and Otsuka Y -
AbpA and AbpB provide anti-phage activity in Escherichia coli
,Genes Genet Syst,89(2):51-60 2014
Yasui R, Washizaki A, Furihata Y, Yonesaki T, and Otsuka Y -
RNase HI stimulates the activity of RnlA toxin in Escherichia coli
,Mol Microbiol,91(3):596-605 2014
Naka K, Koga M, Yonesaki T, and Otsuka Y -
Structure-function studies of Escherichia coli RnlA reveal a novel toxin structure involved in bacteriophage resistance
,Mol Microbiol,90(5):956-965 2013
Wei Y, Gao ZQ, Otsuka Y, Naka K, Yonesaki T, Zhang H, and Dong YH -
Identification of the human PMR1 mRNA endonuclease as an alternatively processed product of the gene for peroxidasin-like protein
,RNA,18(6):1186-1196 2012
Gu SQ, Bakthavachalu B, Han J, Patil DP, Otsuka Y, Guda C, and Schoenberg DR -
Dmd of bacteriophage T4 functions as an antitoxin against Escherichia coli LsoA and RnlA toxins
,Mol Microbiol,83(4):669-681 2012
Otsuka Y, and Yonesaki T -
Escherichia coli rnlA and rnlB compose a novel Toxin–Antitoxin system
,Genetics,187(1):123-130 2011
Koga M, Otsuka Y, Lemire S, and Yonesaki T -
新世代のファージ研究
,生産と技術,62:55-58 2010
米崎哲朗、大塚裕一 -
IscR regulates RNase LS activity by repressing rnlA transcription
,Genetics,185(3):823-830 2010
Otsuka Y, Miki K, Koga M, Katayama N, Morimoto W, Takahashi Y, and Yonesaki T -
Identification of a cytoplasmic complex that adds a cap onto 5'-monophosphate RNA
,Mol Cell Biol,29(8):2155-2167 2009
Otsuka Y, Kedersha NL, and Schoenberg DR -
A role of RnlA in the RNase LS activity from Escherichia coli
,Genes Genet Syst,82(4):291-299 2007
Otsuka Y, Koga M, Iwamoto A, and Yonesaki T -
Polysome-bound endonuclease PMR1 is targeted to stress granules via stress-specific binding to TIA-1
,Mol Cell Biol,26(23):8803-8813 2006
Yang F, Peng Y, Murray EL, Otsuka Y, Kedersha N, and Schoenberg DR -
A novel endoribonuclease, RNase LS, in Escherichia coli
,Genetics,169(1):13-20 2005
Otsuka Y, and Yonesaki T -
大腸菌mRNAの分解
,蛋白質核酸酵素,48:240-246 2003
大塚裕一、米崎哲朗 -
Escherichia coli endoribonucleases involved in cleavage of bacteriophage T4 mRNAs
,J Bacteriol,185(3):983-990 2003
Otsuka Y, Ueno H, and Yonesaki T -
Gene 61.3 of bacteriophage T4 is the spackle gene
,Virology,260(2):254-259 1999
Kai T, Ueno H, Otsuka Y, Morimoto W, and Yonesaki T - Presentation
-
大腸菌の抗ファージ因子AbpA-AbpBの活性化機構の解明
第3回ファージセラピー研究会 202309
滝田彩耶, 大塚裕一 -
DUF4297–HerAによる抗ファージ作用
第1回ファージ若手会 202309
新谷優之介, 大塚裕一 -
トキシンーアンチトキシンシステムの活性化に関わるファージ因子の同定と解析
第1回ファージ若手会 202309
隠岐大稀, 大塚裕一 -
大腸菌の抗ファージ因子AbpA-AbpBの活性化機構の解明
第10回ファージ研究会 202308
滝田彩耶, 大塚裕一 -
大腸菌O157株がもつトキシン-アンチトキシン系ECs3274-ECs3275の解析
第10回ファージ研究会 202308
劉可, 大塚裕一 -
ファージ尾繊維と大腸菌レセプター分子OmpCの相互作用
第10回ファージ研究会 202308
寺﨑陽香, 大塚裕一 -
大腸菌O157株がもつトキシン-アンチトキシン系ECs3274-ECs3275の解析
第96回日本細菌学会総会 202303
佐々木優香, 大塚裕一 -
ファージ尾繊維とレセプター分子OmpCの相互作用
第2回ファージセラピー研究会 202211
寺﨑陽香, 大塚裕一 -
大腸菌AbpAとAbpBによる抗ファージ作用に関連する因子の探索
第9回ファージ研究会 202209
滝田彩耶, 大塚裕一 -
ファージがコードするトキシン-アンチトキシンシステムhokW-sokW の発現制御
第9回ファージ研究会 202209
劉可, 大塚裕一 -
ファージ尾繊維とレセプター分子OmpCの相互作用
第9回ファージ研究会 202209
寺﨑陽香, 大塚裕一 -
大腸菌O157株がもつトキシン–アンチトキシン系ECs3274-ECs3275の解析
第95回日本細菌学会総会 202203
佐々木優香、大塚裕一 -
腸管出血性大腸菌O157株がもつZorOトキシンの作用機序の解明と抗菌ペプチドへの応用
第93回日本細菌学会総会 202002
大塚裕一 -
腸管出血性大腸菌O157株がもつZorOトキシンの作用機序の解明と抗菌ペプチドへの応用
第42回日本分子生物学会年会 201912
大塚裕一 -
細菌とファージとの攻防 〜トキシン・アンチトキシン系〜
第17回微生物研究会「微生物分子生物学のフロンティア」 201811
大塚裕一 -
この世はウイルスだらけ
日本微生物学連盟フォーラム,「微生物:変わり者たちの素顔」 201712
大塚裕一 -
細菌とファージの生存戦略:トキシン-アンチトキシン系の制御
第39回日本分子生物学会年会 201612
大塚裕一 -
細菌のトキシン-アンチトキシン系とファージ感染との関係
第89回日本細菌学会総会 201603
大塚裕一 -
ファージ療法・T4ファージを用いた新しいチャレンジ
日本農芸化学会西日本支部大会シンポジウム 201409
大塚裕一 -
Toxin–Antitoxin Systems in Escherichia coli O157 and Bacteriophage T4 Infection
BIT’s 2nd Annual World Congress of Microbes–2012 201207
Otsuka Yuichi -
トキシン-アンチトキシンとT4ファージ
第3回ファージ研究会「バクテリオファージ研究の可能性と課題」 201008
大塚裕一 -
5' capping of endonuclease-generated decay intermediates by a cytoplasmic capping enzyme complex
Keystone Symposia 2008: Translational Regulatory Mechanisms 200802
Otsuka Yuichi