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OTSUKA Yuichi

Faculty: Department of Biochemistry and Molecular Biology, Graduate School of Science and Engineering TEL: 81-70-8819-4666
Position: Associate Professor ■FAX:
Address: 255 Shimo-Okubo, Sakura-ku, Saitama City, Saitama 338-8570, JAPAN ■Mail Address: otsukay@mail.saitama-u.ac.jp
■Web site:

Profile

Assigned Class

Department of Biochemistry and Molecular Biology, Faculty of Science

Research Field

Molecular Microbiology

Academic Societies

Academic Societies
American Society for Microbiology
THe Molecular Biology Society of Japan
Japanese Society for Bacteriology

Academic Background

Graduate School
Osaka University , (Doctor later , Department of Biological Sciences , Graduate School of Science) , 2003(Completed)
Osaka University , (Doctor prophase , Department of Biological Sciences , Graduate School of Science) , 2000(Completed)
College
Osaka University , (Department of Biological Sciences , Faculty of Science) , 1998(Graduated)
Degree
Doctor of Science , Osaka University

Research Career

Research Career
2018 , Saitama University, Department of Biochemistry and Molecular Biology, Associate Professor
2014 - 2018 , Dokkyo Medical University, School of Medicine, Assistant Professor
2009 - 2014 , Osaka University, Faculty of Science, Department of Biological Sciences, Assistant Professor
2004 - 2009 , The Ohio State University Postdoctoral Fellow

Research

Books, Articles, etc.

Books
Endoribonucleases of the toxin-antitoxin systems induce abortive infection’ in “RNA Damage and Repair”
Springer Nature:Pages 3-26 202107
ISBN:978-3-030-76570-5
Yuichi Otsuka

Approaches for studying PMR1 endonuclease-mediated mRNA decay
Academic Press, USA:241-263 2008
Otsuka Y, and Schoenberg DR

Articles
Phage single-stranded DNA-binding protein or host DNA damage triggers the activation of the AbpAB phage defense system
,mSphere,8(6):e0037223 2023
Takaomi Sasaki, Saya Takita, Takashi Fujishiro, Yunosuke Shintani, Satoki Nojiri, Ryota Yasui, Tetsuro Yonesaki, Yuichi Otsuka

Manipulating interactions between T4 phage long tail fibers and Escherichia coli receptors.
,Appl. Environ. Microbiol. ,87(13):e00423-21 2021
Akiyo Suga, Marina Kawaguchi, Tetsuro Yonesaki, Yuichi Otsuka

The hokW-sokW locus encodes a type I toxin–antitoxin system that facilitates the release of lysogenic Sp5 phage in enterohemorrhagic Escherichia coli O157.
,Toxins (Basel),13(11):796 2021
Kosuke Takada, Kotone Hama, Takaomi Sasaki, Yuichi Otsuka

A short peptide derived from the ZorO toxin functions as an effective antimicrobial.
,Toxins,11(7):392; DOI:10.3390/toxins11070392 2019
Otsuka Y, Ishikawa T, Takahashi C, and Masuda M.

RnlB antitoxin of the Escherichia coli RnlA-RnlB toxin–antitoxin module requires RNase HI for inhibition of RnlA toxin activity
,Toxins,9(1):29 2017
Naka K, Qi D, Yonesaki T, and Otsuka Y

Characterization of the interactions between Escherichia coli receptors, LPS and OmpC, and bacteriophage T4 long tail fibers
,Microbiologyopen,5(6):1003-1015 2016
Washizaki A, Yonesaki T, and Otsuka Y

Structural insights into the inhibition mechanism of bacterial toxin LsoA by bacteriophage antitoxin Dmd
,Mol Microbiol,101(5):757-769 2016
Wan H, Otsuka Y, Gao ZQ, Wei Y, Chen Z, Masuda M, Yonesaki T, Zhang H, and Dong YH

Prokaryotic toxin–antitoxin systems: novel regulations of the toxins
,Curr Genet,62(2):379-382 2016
Otsuka Y, and Schoenberg DR

An ADP-ribosyltransferase Alt of bacteriophage T4 negatively regulates the Escherichia coli MazF toxin of a toxin–antitoxin module
,Mol Microbiol,99(1):188-198 2016
Alawneh AM, Qi D, Yonesaki T, and Otsuka Y

Rapid degradation of host mRNAs by stimulation of RNase E activity by Srd of bacteriophage T4
,Genetics,201(3):977-987 2015
Qi D, Alawneh AM, Yonesaki T, and Otsuka Y

AbpA and AbpB provide anti-phage activity in Escherichia coli
,Genes Genet Syst,89(2):51-60 2014
Yasui R, Washizaki A, Furihata Y, Yonesaki T, and Otsuka Y

RNase HI stimulates the activity of RnlA toxin in Escherichia coli
,Mol Microbiol,91(3):596-605 2014
Naka K, Koga M, Yonesaki T, and Otsuka Y

Structure-function studies of Escherichia coli RnlA reveal a novel toxin structure involved in bacteriophage resistance
,Mol Microbiol,90(5):956-965 2013
Wei Y, Gao ZQ, Otsuka Y, Naka K, Yonesaki T, Zhang H, and Dong YH

Identification of the human PMR1 mRNA endonuclease as an alternatively processed product of the gene for peroxidasin-like protein
,RNA,18(6):1186-1196 2012
Gu SQ, Bakthavachalu B, Han J, Patil DP, Otsuka Y, Guda C, and Schoenberg DR

Dmd of bacteriophage T4 functions as an antitoxin against Escherichia coli LsoA and RnlA toxins
,Mol Microbiol,83(4):669-681 2012
Otsuka Y, and Yonesaki T

Escherichia coli rnlA and rnlB compose a novel Toxin–Antitoxin system
,Genetics,187(1):123-130 2011
Koga M, Otsuka Y, Lemire S, and Yonesaki T

新世代のファージ研究
,生産と技術,62:55-58 2010
米崎哲朗、大塚裕一

IscR regulates RNase LS activity by repressing rnlA transcription
,Genetics,185(3):823-830 2010
Otsuka Y, Miki K, Koga M, Katayama N, Morimoto W, Takahashi Y, and Yonesaki T

Identification of a cytoplasmic complex that adds a cap onto 5'-monophosphate RNA
,Mol Cell Biol,29(8):2155-2167 2009
Otsuka Y, Kedersha NL, and Schoenberg DR

A role of RnlA in the RNase LS activity from Escherichia coli
,Genes Genet Syst,82(4):291-299 2007
Otsuka Y, Koga M, Iwamoto A, and Yonesaki T

Polysome-bound endonuclease PMR1 is targeted to stress granules via stress-specific binding to TIA-1
,Mol Cell Biol,26(23):8803-8813 2006
Yang F, Peng Y, Murray EL, Otsuka Y, Kedersha N, and Schoenberg DR

A novel endoribonuclease, RNase LS, in Escherichia coli
,Genetics,169(1):13-20 2005
Otsuka Y, and Yonesaki T

大腸菌mRNAの分解
,蛋白質核酸酵素,48:240-246 2003
大塚裕一、米崎哲朗

Escherichia coli endoribonucleases involved in cleavage of bacteriophage T4 mRNAs
,J Bacteriol,185(3):983-990 2003
Otsuka Y, Ueno H, and Yonesaki T

Gene 61.3 of bacteriophage T4 is the spackle gene
,Virology,260(2):254-259 1999
Kai T, Ueno H, Otsuka Y, Morimoto W, and Yonesaki T

Presentation
大腸菌の抗ファージ因子AbpA-AbpBの活性化機構の解明
第3回ファージセラピー研究会 202309
滝田彩耶, 大塚裕一

DUF4297–HerAによる抗ファージ作用
第1回ファージ若手会 202309
新谷優之介, 大塚裕一

トキシンーアンチトキシンシステムの活性化に関わるファージ因子の同定と解析
第1回ファージ若手会 202309
隠岐大稀, 大塚裕一

大腸菌の抗ファージ因子AbpA-AbpBの活性化機構の解明
第10回ファージ研究会 202308
滝田彩耶, 大塚裕一

大腸菌O157株がもつトキシン-アンチトキシン系ECs3274-ECs3275の解析
第10回ファージ研究会 202308
劉可, 大塚裕一

ファージ尾繊維と大腸菌レセプター分子OmpCの相互作用
第10回ファージ研究会 202308
寺﨑陽香, 大塚裕一

大腸菌O157株がもつトキシン-アンチトキシン系ECs3274-ECs3275の解析
第96回日本細菌学会総会 202303
佐々木優香, 大塚裕一

ファージ尾繊維とレセプター分子OmpCの相互作用
第2回ファージセラピー研究会 202211
寺﨑陽香, 大塚裕一

大腸菌AbpAとAbpBによる抗ファージ作用に関連する因子の探索
第9回ファージ研究会 202209
滝田彩耶, 大塚裕一

ファージがコードするトキシン-アンチトキシンシステムhokW-sokW の発現制御
第9回ファージ研究会 202209
劉可, 大塚裕一

ファージ尾繊維とレセプター分子OmpCの相互作用
第9回ファージ研究会 202209
寺﨑陽香, 大塚裕一

大腸菌O157株がもつトキシン–アンチトキシン系ECs3274-ECs3275の解析
第95回日本細菌学会総会 202203
佐々木優香、大塚裕一

腸管出血性大腸菌O157株がもつZorOトキシンの作用機序の解明と抗菌ペプチドへの応用
第93回日本細菌学会総会 202002
大塚裕一

腸管出血性大腸菌O157株がもつZorOトキシンの作用機序の解明と抗菌ペプチドへの応用
第42回日本分子生物学会年会 201912
大塚裕一

細菌とファージとの攻防 〜トキシン・アンチトキシン系〜
第17回微生物研究会「微生物分子生物学のフロンティア」 201811
大塚裕一

この世はウイルスだらけ
日本微生物学連盟フォーラム,「微生物:変わり者たちの素顔」 201712
大塚裕一

細菌とファージの生存戦略:トキシン-アンチトキシン系の制御
第39回日本分子生物学会年会 201612
大塚裕一

細菌のトキシン-アンチトキシン系とファージ感染との関係
第89回日本細菌学会総会 201603
大塚裕一

ファージ療法・T4ファージを用いた新しいチャレンジ
日本農芸化学会西日本支部大会シンポジウム 201409
大塚裕一

Toxin–Antitoxin Systems in Escherichia coli O157 and Bacteriophage T4 Infection
BIT’s 2nd Annual World Congress of Microbes–2012 201207
Otsuka Yuichi

トキシン-アンチトキシンとT4ファージ
第3回ファージ研究会「バクテリオファージ研究の可能性と課題」 201008
大塚裕一

5' capping of endonuclease-generated decay intermediates by a cytoplasmic capping enzyme complex
Keystone Symposia 2008: Translational Regulatory Mechanisms 200802
Otsuka Yuichi