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TOYOTA Masatsugu

Faculty: Department of Biochemistry and Molecular Biology TEL:
Position: Professor  Honorary Fellow   ■FAX:
Address: 255 Shimo-Okubo, Sakura-ku, Saitama City, Saitama 338-8570, JAPAN ■Mail Address:
■Web site:

Profile

Assigned Class

Department of Botany, University of Wisconsin-Madison

Research Field

Biophysics
Plant Physiology
keyword:Live-cell imaging , Microscopy , Long-distance signaling , Mechanobiology , Ion channel , Electrophysiology

Academic Societies

Academic Societies
The Botanical Society of Japan
The Biophysical Society of Japan
The Japanese Society of Plant Physiologists
The American Society of Plant Biologists

Academic Background

Graduate School
Nagoya University , (Doctor course , Cell Information Medicine , Graduate School of Medicine) , 2008(Completed)
Nagoya University , (Doctor prophase , Division of Material Science (Physics) , Graduate School of Science) , 2004(Completed)
College
Nagoya University , (Department of Physics , School of Science) , 2002(Graduated)
Degree
Ph.D. in Medical Science , Nagoya University

Awards

2020
2017
2017
2015 , The Early Career Award in Biophysics
2014 , The Naito Conference Best Presentation Award
2014 , Keystone Symposia Future of Science Fund Scholarship
2013 , American Society of Plant Biologists Travel Award
2012 , Midwest Plant Cell Dynamics Meeting Travel Award
2010 , RIKEN GSC Tanabata Fellow
2004 , Iwadare Fellowship

Research Career

Research Career
2016 , Honorary Fellow (University of Wisconsin-Madison)
2016 - 2016 , Nagoya University S-YLC Assistant Professor
2014 - 2017 , Japan Science and Technology Agency PRESTO Researcher
2014 - 2016 , Assistant Scientist (University of Wisconsin-Madison)
2012 - 2014 , Japan Society for the Promotion of Science Postdoctoral Fellow for Research Abroad (University of Wisconsin-Madison)
2011 - 2014 , Research Associate (University of Wisconsin-Madison)
2011 - 2012 , TOYOBO Biotechnology Foundation Postdoctoral Fellow (University of Wisconsin-Madison)
2008 - 2011 , Japan Society for the Promotion of Science Postdoctoral Fellow (PD) (NAIST)
2005 - 2008 , Japan Society for the Promotion of Science Research Fellow (DC1) (Nagoya University)

Research

Books, Articles, etc.

Books
重力感知のメカノバイオロジーⅢ:植物細胞
メカノバイオロジー: 細胞が力を感じ応答する仕組み (DOJIN BIOSCIENCE SERIES) (曽我部正博 編) 化学同人:125-139 2015
豊田正嗣

Mini-history of map-based cloning in Arabidopsis
Cleaved amplified polymorphic sequences (CAPS) markers in plant biology, ed Shavrukov Y (Nova Science Publishers, Inc., New York, USA):1-20 2014
Kato T, Toyota M, Tasaka M, Morita MT

植物の重力(機械)刺激受容機構の解明に向けて
JAROS 宇宙環境利用の展望:1-30 2011
豊田正嗣

Articles
Mechanosensory trichome cells evoke a mechanical stimuli-induced immune response in Arabidopsis thaliana.
,Nature Communications,13:1216 2022
Matsumura M, Nomoto M, Itaya T, Aratani Y, Iwamoto M, Matsuura T, Hayashi Y, Mori T, Skelly MJ, Yamamoto YY, Kinoshita T, Mori IC, Suzuki T, Betsuyaku S, Spoel SH, Toyota M, Tada Y

Gravity sensing in plant and animal cells
,npj Microgravity,7:2 2021
Takahashi K, Takahashi H, Furuichi F, Toyota M, Furutani-Seiki M, Kobayashi T, Watanabe-Takano H, Shinohara M, Numaga-Tomita T, Sakaue-Sawano A, Miyawaki A, Naruse K

CYCLIC NUCLEOTIDE-GATED ION CHANNEL 2 modulates auxin homeostasis and signaling
,Plant Physiology,187:1690–1703 2021
Chakraborty S, Toyota M, Moeder W, Chin K, Fortuna A, Champigny M, Vanneste S, Gilroy S, Beeckman T, Nambara E, Yoshioka K

The fast and the furious: rapid long-range signaling in plants
,Plant Physiology,185:694-706 2021
Johns S, Hagihara T, Toyota M, Gilroy S

Wide-field, real-time imaging of local and systemic wound signals in Arabidopsis
,Journal of Visualized Experiments,172:e62114 2021
Uemura T, Wang J, Aratani Y, Gilroy S, Toyota M

植物の長距離・高速Ca2+シグナル
,生物物理,62:56-57 2021
豊田正嗣

Tonoplast-localized Ca2+ pumps regulate Ca2+ signals during pattern-triggered immunity in Arabidopsis thaliana.
,Proceedings of the National Academy of Sciences USA,117:18849-18857 2020
Hilleary R, Paez-Valencia J, Vens C, Toyota M, Palmgren M, Gilroy S

Calcium dynamics during trap closure visualized in transgenic Venus flytrap
,Nature Plants,6:1219-1224 2020
Suda H, Mano H, Toyota M, Fukushima K, Mimura T, Tsutsui I, Hedrich R, Tamada Y, Hasebe M

Micromanipulation of amyloplasts with optical tweezers in Arabidopsis stems
,Plant Biotechnology,37:405-415 2020
Abe Y, Meguriya K, Matsuzaki T, Sugiyama T, Yoshikawa HY, Morita MT, Toyota M

若手研究者の現状 ―アメリカでの苦悩と挑戦―
,植物の生長調節,55:70-73 2020
豊田正嗣

植物が傷つけられたことを感じて,全身に情報を伝える仕組み:グルタミン酸の新しい機能
,化学と生物,58:70-72 2020
豊田正嗣

CRK2 and C-terminal Phosphorylation of NADPH Oxidase RBOHD Regulate Reactive Oxygen Species Production in Arabidopsis
,Plant Cell,32:1063-1080 2020
Kimura S, Hunter K, Vaahtera L, Tran HC, Citterico M, Vaattovaara A, Rokka A, Stolze SC, Harzen A, Meissner L, Wilkens MMT, Hamann T, Toyota M, Nakagami H, Wrzaczek M

Mechanical Signaling in the Sensitive Plant Mimosa pudica L
,Plants,9:587 2020
Hagihara T, Toyota M

植物の全身カルシウムイメージング
,アグリバイオ,3(2):23 - 27 2019
豊田正嗣

植物におけるカルシウム/グルタミン酸のリアルタイムイメージング
,バイオサイエンスとインダストリー,77(2):110-111 2019
豊田正嗣

グルタミン酸はカルシウムシグナルを介して植物の全身性傷害防御を引き起こす
,バイオサイエンスとインダストリー,77(2):134-135 2019
豊田正嗣

植物の全身を流れる高速シグナルを見る
,日経バイオテク(902):44-46 2019
豊田正嗣

「かじられた!」とぺんぺん草もシグナルを送る
,Nextcom ,39:42-43 2019
豊田正嗣

CRK2 Enhances Salt Tolerance by Regulating Callose Deposition in Connection with PLDalpha1
,Plant Physiology ,180:2004-2021 2019
Hunter K, Kimura S, Rokka A, Tran HC, Toyota M, Kukkonen JP, Wrzaczek M

Molecular Mechanisms of Mechanosensing and Mechanotransduction
,Plant Biomechanics:375-397 2018
Toyota M, Furuichi T, Iida H

Glutamate triggers long-distance, calcium-based plant defense signaling.
,Science,361:1112-1115 2018
Toyota M, Spencer D, Sawai-Toyota S, Wang J, Zhang T, Koo AJ, Howe GA, Gilroy S

植物が傷つけられたことを全身へ伝えるしくみを解明!
,月刊「化学」,73(11):73 2018
豊田正嗣

グルタミン酸とカルシウムシグナルを介した傷害応答
,植物の生長調節 ,53(2):146-151 2018
豊田正嗣

Control of basal jasmonate signalling and defence through modulation of intracellular cation flux capacity
,New Phytologist ,216:1161-1169 2017
Lenglet A, Jaslan D, Toyota M, Mueller M, Muller T, Schonknecht G, Marten I, Gilroy S, Hedrich R, Farmer EE

The Arabidopsis LAZY1 Family Plays a Key Role in Gravity Signaling within Statocytes and in Branch Angle Control of Roots and Shoots
,Plant Cell,29:1984-1999 2017
Taniguchi M, Furutani M, Nishimura T, Nakamura M, Fushita T, Iijima K, Baba K, Tanaka H, Toyota M, Tasaka M, Morita MT

Real-time In Vivo Recording of Arabidopsis Calcium Signals During Insect Feeding Using a Fluorescent Biosensor
,Journal of Visualized Experiments,126 2017
Vincent T, Canham J, Toyota M, Avramova M, Mugford S, Gilroy S, Miller A, Hogenhout S, Sanders S

Interplay of Plasma Membrane and Vacuolar Ion Channels, Together with BAK1, Elicits Rapid Cytosolic Calcium Elevations in Arabidopsis during Aphid Feeding.
,Plant Cell,29:1460-1479 2017
Vincent TR, Avramova M, Canham J, Higgins P, Bilkey N, Mugford ST, Pitino M, Toyota M, Gilroy S, Miller AJ, Hogenhout SA, Sanders D

Using GCaMP3 To Study Ca2+ Signaling In Nicotiana Species
,Plant Cell Physiolgy,58:1173-1184 2017
DeFalco TA, Toyota M, Phan V, Karia P, Moeder W, Gilroy S, Yoshioka K

Wortmannin-induced vacuole fusion enhances amyloplast dynamics in Arabidopsis zigzag1 hypocotyls
,Journal of Experimental Botany,67:6459-6472 2016
Alvarez A, Han SW, Toyota M, Brillada C, Zheng J, Gilroy S, Rojas-Pierce M

Isolation of new gravitropic mutants under hypergravity conditions
,Frontiers in Plant Science,7:1443 2016
Mori A, Toyota M, Shimada M, Mekata M, Kurata T, Tasaka M, Morita MT

Live cell imaging of cytoskeletal and organelle dynamics in gravity-sensing cells in plant gravitropism
,Methods in Molecular Biology,1309:57-69 2015
Nakamura M, Toyota M, Tasaka M, Morita MT

Mechanosensitive channels are activated by stress in the actin stress fibres, and could be involved in gravity sensing in plants
,Plant Biology ,16:18-22 2014
Tatsumi H, Furuichi T, Nakano M, Toyota M, Hayakawa K, Sokabe M, Iida H

Calcium mobilizations in response to changes in the gravity vector in Arabidopsis seedlings: Possible cellular mechanisms
,Plant Signaling & Behavior,9:e29099 2014
Tatsumi H, Toyota M, Furuichi T, Sokabe M

New candidates for mechano-sensitive channels potentially involved in gravity sensing in Arabidopsis thaliana
,Plant Biology,16:39-42 2014
Iida H, Furuichi T, Nakano M, Toyota M, Sokabe M, Tatsumi H

A tidal wave of signals: calcium and ROS at the forefront of rapid systemic signaling
,Trends in Plant Science,19:623-630 2014
Gilroy S, Suzuki N, Miller G, Choi WG, Toyota M, Devireddy AR, Mittler R

Salt stress-induced Ca2+ waves are associated with rapid, long-distance root-to-shoot signaling in plants
,Proceedings of the National Academy of Sciences of the United States of America,111:6497-6502 2014
Choi WG, Toyota M, Kim SH, Hilleary R, Gilroy S

Centrifuge microscopy to analyze the sedimentary movements of amyloplasts
,Bio-protocol,4:e1229 2014
Toyota M, Ikeda N, Tasaka M, Morita MT

Amyloplast displacement is necessary for gravisensing in Arabidopsis shoots as revealed by a centrifuge microscope
,Plant Journal,76:648-660 2013
Toyota M, Ikeda N, Sawai-Toyota S, Kato T, Gilroy S, Tasaka M, Morita MT

Gravitropism and mechanical signaling in plants
,American Journal Botany,100:111-125 2013
Toyota M, Gilroy S

Analyses of a gravistimulation-specific Ca2+ signature in Arabidopsis using parabolic flights
,Plant Physiology,163:543-554 2013
Toyota M, Furuichi T, Sokabe M, Tatsumi H

重力感受をライブで視るための新しい顕微鏡技術
,Plant Morphology,24:23-32 2012
豊田正嗣, 森田(寺尾)美代, 池田憲文, 田坂昌生

Developmental changes in crossover frequency in Arabidopsis
,Plant Journal,65:589-599 2011
Toyota M, Matsuda K, Kakutani T, Morita MT, Tasaka M

An Arabidopsis E3 ligase, SHOOT GRAVITROPISM9, modulates the interaction between statoliths and F-actin in gravity sensing
,Plant Cell,23:1830-1848 2011
Nakamura M, Toyota M, Tasaka M, Morita MT

植物の重力感受機構モデル~デンプン平衡石仮説~の再検証
,生化学,82:730-734 2010
豊田正嗣, 森田(寺尾)美代

Critical consideration on the relationship between auxin transport and calcium transients in gravity perception of Arabidopsis seedlings
,Plant Signaling & Behavior,3:521-524 2008
Toyota M, Furuichi T, Tatsumi H, Sokabe M

Cytoplasmic calcium increases in response to changes in the gravity vector in hypocotyls and petioles of Arabidopsis seedlings
,Plant Physiology,146:505-514 2008
Toyota M, Furuichi T, Tatsumi H, Sokabe M

Hypergravity stimulation induces changes in intracellular calcium concentration in Arabidopsis seedlings
,Advances in Space Research,39:1190-1197 2007
Toyota M, Furuichi T, Tatsumi H, Sokabe M

Presentation
感じる植物、動く植物
第5回 大隅基礎科学創成財団 小中高生と最先端研究者とのふれ合いの集い 202203
豊田正嗣

ハエトリソウの高速運動を司るセンサーとアクチュエータ
第63回日本植物生理学会年会 202203
須田啓, 浅川裕紀, 津川暁, 豊田正嗣

カルシウムシグナルを介した植物内・植物間情報伝達の可視化
第69回日本生態学会大会(ESJ69) 202203
豊田正嗣

Dynamic mechanosensory Ca2+ signaling in plants
東北大学生命科学研究科 個体ダイナミクスセミナーシリーズ 202111
豊田正嗣

植物の長距離・高速情報伝達を視る
生理学研究所研究会「極限環境適応」 202111
豊田正嗣

Mechanosensory transduction in plants
RIMS Workshop Mathematical Mechanobiology 202107
Toyota M

Plant-wide calcium defense signaling
THE 31st INTERNATIONAL CONFERENCE ON ARABIDOPSIS RESEARCH (ICAR 2021) 202106
Toyota M

植物のメカノバイオロジー
RIMS Tutorial Seminar 生物の創るパターンとダイナミクス:基礎からの展開 202106
豊田正嗣

植物に神経はあるのか? -長距離・高速Ca2+シグナルを介した植物の虫害抵抗性反応-
第4回大隅基礎科学創成財団創発セミナー 202101
豊田正嗣

植物の長距離・高速カルシウムシグナルを可視化する
日本応用糖質科学会 202012
豊田正嗣

大きな植物をまるごと可視化する ~広視野・高速カルシウムイメージングの挑戦~
情報分子可視化技術勉強会 202009
豊田正嗣

虫にかじられた植物が発する緊急信号を見る
第84回日本植物学会大会 202009
豊田正嗣

海外どうですか? 〜欧・⽶・アジア、⽐べて⾒えてくる多様な研究ライフ〜
第84回日本植物学会大会 202009
豊田正嗣

Calcium-based intra- and inter-plant communication system
第61回日本植物生理学会 202003
Toyota M

Strategies of mechanical optimization for plant wound responses
Strategies of mechanical optimization in plants 201912
Toyota M

グルタミン酸受容体を介した植物の長距離カルシウムシグナル
日本顕微鏡学会 第62回シンポジウム 201911
豊田正嗣

Long-distance, rapid calcium signaling in plant
Frontiers in plant environmental response research: local signaling, long-distance communication and memory for developmental plasticity 201911
Toyota M

Long-range, rapid calcium signaling in plants
ViPS Seminar (Viikki Plant Science Centre) 201911
Toyota M

Long-distance Ca2+ transmission via glutamate receptor channels in plants
第57回日本生物物理学会 201909
Toyota M

Real-time imaging of whole-plant calcium and glutamate dynamics
The 6th International Symposium on Bioimaging The 28th Annual Meeting of the Bioimaging Society of Japan BIOIMAGING 2019 201909
Toyota M

グルタミン酸受容体/カルシウムシグナルを介した植物の全身性傷害応答
令和元年度 日本植物病理学会関東部会 201909
豊田正嗣

Ca2+シグナルを介した植物の全身性傷害応答
第32回植物脂質シンポジウム 201909
豊田正嗣

植物のメカノバイオロジー -傷害受容を例にして-
日本メカノバイオロジー研究会 2019 201909
豊田正嗣

Glutamate is a wound signal triggering systemic calcium propagation
The 23rd International Conference on Plant Growth Substances 201906
Toyota M

Long-distance rapid Ca2+ and electrical signals in Mimosa pudica
Japan-Taiwan Plant Biology 2019 201903
Hagihara T, Miura T, Mano H, Hasebe M, Toyota M

高感度バイオセンサーを用いた植物の構造力学的研究
日本植物生理学会 201903
豊田正嗣

Systemic calcium signaling via glutamate receptor channels in response to mechanical wounding
IPSR symposium 201903
Toyota M

GCaMPが切り拓く植物科学の新しい地平線
第100回 埼玉大学脳科学センター 201901
豊田正嗣

植物の機械(重力)刺激受容機構の生物物理学的研究
日本植物学会 201809
豊田正嗣

Long-range calcium transmission as revealed by whole-plant imaging
"Frontiers in whole-brain/whole-organ imaging of cellular activities" Saitama University Brain and Body System Science Institute (BBSSI) International Symposium, Nov 21, Saitama, Japan 201711
Toyota M

科学者とは? ~星の数ほど存在する無限の可能性~
日本宇宙生物科学会 201709
豊田 正嗣

Systemic calcium waves in plants
EMBO Workshop -Intercellular communication in development and disease, July 10-15, Berlin, Germany 201707
Toyota M

Long-range symplastic calcium transmission in plants
RIKEN CSRS seminar 201707
Toyota M

Molecular mechanisms underlying wound-induced rapid systemic calcium signaling
Plant Biology 2016 (American Society of Plant Biologist),July 12, Austin, TX, USA 2016
Toyota M, Gilroy S

Glutamate-triggered rapid systemic Ca2+ transmission in wound sensing.
Cold Spring Harbor Asia,Nov 30, Awajishima, Hyogo, Japan 2016
Toyota M, Gilroy S

Increase in the Cytoplasmic Free Calcium Ion Concentration in Response to Changes in the Gravity Vector in Arabidopsis Seedlings
ASM2016:Oct 27, Sapporo, Japan 2016
Tatsumi H, Nakano M, Toyota M, Iida H, Sokabe M, Furuichi T

Mechanical wounding/insect attack-induced, long-distance, rapid calcium signal transduction in plants
The 53rd Biophysical Society of Japan Annual Meeting,Sep 13, Kanazawa, Japan. 2015
Toyota M, Gilroy S

Mechanical wounding/insect attack-induced, long-distance, rapid calcium signal transduction in plants.
Midwest Plant Cell Dynamics Meeting,June 16-19, Madison, WI, USA 2015
Toyota M, Gilroy S

Visualization of plant-wide rapid calcium signals underlying systemic resistance responses
The 56th Japanese Society of Plant Physiologists Annual Meeting ,March 16-18, Tokyo, Japan 2014
Toyota M, Gilroy S

Mechanical wounding/herbivore attack-induced, long-distance, rapid Ca2+ signal transduction via the phloem
The 38th Naito Conference "Molecule-based biological systems",Oct 7-10, Sapporo, Japan. 2014
Toyota M, Gilroy S

Wound-induced rapid systemic Ca2+ transmission through the phloem
Keystone Symposia "Plant Signaling: Dynamic Properties",Feb 6, Breckenridge, CO, USA 2014
Toyota M, Gilroy S

Long-range rapid Ca2+ transmission through the phloem caused by mechanical wounding and herbivore attack.
Plant Biology 2014 (American Society of Plant Biologist):,Jul 12-16, Portland, OR, USA 2014
Toyota M, Gilroy S

Wound-induced rapid systemic Ca2+ signaling in Arabidopsis
Plant Biology 2013 (American Society of Plant Biologist),July 21, Providence, RI, USA 2013
Toyota M, Sawai-Toyota S, Gilroy S

Wound-induced rapid systemic calcium transmission in Arabidopsis
Midwest Plant Cell Dynamics Meeting,June 5, Madison, WI, USA 2013
Toyota M, Gilroy S

A new centrifuge microscope reveals that mobile plastids trigger gravity sensing in Arabidopsis inflorescence stems
The 39th COSPAR Scientific Assembly,July 17, Mysore, India 2012
Toyota M, Tasaka M, Gilroy S, Morita MT

A new centrifuge microscope reveals that mobile plastids trigger gravity sensing in Arabidopsis inflorescence stems
Midwest Plant Cell Dynamics Meeting,June 20-22, Madison, WI, USA 2012
Toyota M, Gilroy S

A centrifuge microscope reveals that mobile plastids trigger gravity sensing in Arabidopsis shoots
American Society for Gravitational and Space Biology (ASGSB) the 27th Annual Meeting / International Society for Gravitational Physiology (ISGP) the 32nd Annual Meeting,Nov 3, San Jose, CA, USA 2011
Toyota M, Tasaka M, Gilroy S, Morita MT

High-resolution imaging of statolith dynamics under hypergravity conditions by using a new centrifuge microscope
22nd International Conference on Arabidopsis Research,June 22-25, Madison, WI, USA 2011
Toyota M, Tasaka M, Morita MT

Analysis of amyloplast dynamics involved in gravity sensing using a novel centrifuge microscope
The 38th COSPAR Scientific Assembly,July 18-25, Bremen, Germany 2010
Toyota M, Tasaka M, Morita MT

Analysis of amyloplast dynamics involved in gravity sensing using a novel centrifuge microscope
Memorial Symposium for the 25th International Prize for Biology,Dec 2-4, Kyoto, Japan 2009
Toyota M, Tasaka M, Morita MT

Investigation of mechanism for gravity sensing in Arabidopsis inflorescence stems using a novel centrifuge microscope
Plant Biology 2009 (American Society of Plant Biologist),July 18-22, Honolulu, HI, USA 2009
Toyota M, Tasaka M, Morita MT

Evidence for gravity-induced calcium response in Arabidopsis under microgravity condition
20th International Conference on Arabidopsis Research,June 30-July 34, Edinburgh, UK 2009
Toyota M, Furuichi T, Tatsumi H, Sokabe M

Analysis of gravi-induced intracellular calcium-increases in Arabidopsis seedlings under 1 g and microgravity condition
Gordon Research Conferences,July 22-27, University of New England, Biddeford, ME, USA 2007
Toyota M, Furuichi T, Tatsumi H, Sokabe M

Gravity-induced calcium transient devoid of amyloplast contribution may be involved in an early phase of gravitropism in Arabidopsis
Fifth East Asian Biophysics Symposium & Forty-Fourth Annual Meeting of the Biophysical Society of Japan,Nov 12-16, Okinawa Convention Center, Okinawa, Japan 2006
Toyota M, Furuichi T, Tatsumi H, Sokabe M

Calcium transient in response to gravity change in Arabidopsis seedlings
Gordon Research Conferences,July 24-29, University of New England, Biddeford, ME, USA 2005
Toyota M, Furuichi T, Tatsumi H, Sokabe M

Cytoplasmic calcium transient induced by gravity vector changes in Arabidopsis seedlings.
Plant Biology 2005 (American Society of Plant Biologist),July 16-20, Seattle, WA, USA 2005
Toyota M, Furuichi T, Tatsumi H, Sokabe M

Research Grants

Cooperative research with industry
2020-2022 , 国立研究開発法人 科学技術振興機構(JST)A-STEP「産学共同(育成型)」
2016-2017 , 公益財団法人 内藤記念科学振興財団 内藤記念特定研究助成金(研究代表)
2014-2017 , 国立研究開発法人 科学技術振興機構(JST)さきがけ(研究代表)