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OTOSU Takuhiro

Faculty: Graduate School of Science and Engineering TEL:
Position: Associate Professor ■FAX:
Address: 255 Shimo-Okubo, Sakura-ku, Saitama City, Saitama 338-8570, JAPAN ■Mail Address:
■Web site:

Profile

Assigned Class

Faculty of Engineering

Academic Background

Graduate School
Kyushu University , (Doctor later) , 2009(Completed)
Kyushu University , (Doctor prophase) , 2006
College
Kyushu University , (Department of Agriculture) , 2004(Graduated)
Degree
Doctor (Agriculture) , Kyushu University

Awards

2013

Research

Books, Articles, etc.

Books
Advanced Photon Counting: Applications, Methods, Instrumentation
Springer:111-128 201505

Articles
Peripheral Adsorption of Polylysine on One Leaflet of a Lipid Bilayer Reduces the Lipid Diffusion of both Leaflets
,Physical Chemistry Chemical Physics,26:8873-8878 2024
Kosei Shimizu, Miyuki Sakaguchi, Shoichi Yamaguchi and Takuhiro Otosu

Theoretical and Experimental OD-stretch Vibrational Spectroscopy of HeavyWater
,The Journal of Chemical Physics,160:104504 2024
Tetsuyuki Takayama, Takuhiro Otosu, Shoichi Yamaguchi

Transferability of Vibrational Spectroscopic Map from TIP4P to TIP4P-like Water Models
,The Journal of Chemical Physics,158:136101 2023
Tetsuyuki Takayama, Takuhiro Otosu, Shoichi Yamaguchi

Appraisal of TIP4P-type Models at Water Surface
,The Journal of Chemical Physics,159:171101 2023
Shoichi Yamaguchi, Tetsuyuki Takayama, Takuhiro Otosu,

Raman Spectroscopy of Isotopically Pure and Diluted High- and Low-density Amorphous Ices
,J. Raman. Spectrosc.,53:1773-1784 2022
Senri Ishihara, Tetsuyuki Takayama, Miyuki Sakaguchi, Takuhiro Otosu, Takuma Yagasaki, Yoshiharu Suzuki, and Shoichi Yamaguchi

Experimental and Theoretical Raman Spectroscopy of Isotopically Pure and Diluted Ice VI
,The Journal of Physical Chemistry C,12:17359-17365 2022
Tetsuyuki Takayama, Kota Kishi, Takuhiro Otosu, Takuma Yagasaki, and Shoichi Yamaguchi

Experimental and Theoretical Heterodyne-Detected Sum Frequency Generation Spectroscopy of Isotopically Pure and Diluted Water Surfaces
,The Journal of Physical Chemistry Letters,13:9649-9653 2022
Shoichi Yamaguchi, Tetsuyuki Takayama, Yuki Goto, Takuhiro Otosu, Takuma Yagasaki

Progress in Phase-sensitive Sum Frequency Generation Spectroscopy
, Phys. Chem. Chem. Phys,23:18253-18267 2021
Shoichi Yamaguchi and Takuhiro Otosu

Effect of Electrostatic Interaction on the Leaflet-specific Lipid Diffusion in a Supported Lipid Bilayer Revealed by Fluorescence Lifetime Correlation Analysis
,Phys. Chem. Chem. Phys.,22:1242-1249 2020
Takuhiro Otosu and Shoichi Yamaguchi

Leaflet-specific Lipid Diffusion Revealed by Fluorescence Lifetime Correlation Analyses
,Chemistry Letters,49:1473 2020
Takuhiro Otosu* and Shoichi Yamaguchi*

Multifocus Fluorescence Correlation Spectroscopy with Spatially Separated Excitation Beams
,Bull. Chem. Soc. Japan ,92:1495-1502 2019
Takuhiro Otosu, Kunihiko Ishii, and Tahei Tahara

Perspective on Sum Frequency Generation Spectroscopy of Ice Surfaces and Interfaces
,Chemical Physics,522:199-210 2019
Shoichi Yamaguchi, Yudai Suzuki, Yuki Nojima, and Takuhiro Otosu

Reduction of Glass-surface Charge Density Slows the Lipid Diffusion in the Proximal Leaflet of a Supported Lipid Bilayer
,Journal of Chemical Physics,151:25102 2019
Takuhiro Otosu and Shoichi Yamaguchi

Local pH at the surface of hen egg white lysozyme
,Chemical Physics Letter,693:165-169 2018
Takuhiro Otosu, Kaito Kobayashi, and Shoichi Yamaguchi

Total Internal Reflection Two-dimensional Fluorescence Lifetime Correlation Spectroscopy
,Journal of Physical Chemistry B,122:5758-5764 2018
Takuhiro Otosu and Shoichi Yamaguchi

Two-dimensional Fluorescence Lifetime Correlation Spectroscopy: Concepts and Applications
,Molecules,23:2972 2018
Takuhiro Otosu and Shoichi Yamaguchi

Quantifying the Diffusion of Lipids in the Proximal/Distal Leaflets of a Supported Lipid Bilayer by Two-dimensional Fluorescence Lifetime Correlation Spectroscopy
,Journal of Physical Chemistry B,122:10315-10319 2018
Takuhiro Otosu and Shoichi Yamaguchi

Highly Heterogeneous Nature of the Native and Unfolded States of the B Domain of Protein A Revealed by Two-Dimensional Fluorescence Lifetime Correlation Spectroscopy
,Journal of Physical Chemistry B,121:5463-5473 2017
Takuhiro Otosu, Kunihiko Ishii, Hiroyuki Oikawa, Munehito Arai, Satoshi Takahashi, and Tahei Tahara

Communication: Development of Standing Evanescent-wave Fluorescence Correlation Spectroscopy and its Application to the Lateral Diffusion of Lipids in a Supported Lipid Bilayer
,Journal of Chemical Physics,147:041101 2017
Takuhiro Otosu and Shoichi Yamaguchi

Microsecond protein dynamics observed at the single-molecule level
,Nature Communications,6:7685 2015
Takuhiro Otosu, Kunihiko Ishii, and Tahei Tahara

Lifetime-weighted FCS and 2D FLCS: Advanced application of time-tagged TCSPC
,Advanced Photon Counting: Applications, Methods, Instrumentation 2015
Kunihiko Ishii, Takuhiro Otosu, Tahei Tahara

二次元蛍光寿命相関分光法によるマイクロ秒蛋白質 ダイナミクス
,生物物理,316 2014
乙須拓洋

Simple Calibration of the Counting-rate Dependence of the Timing Shift of Single Photon Avalanche Diodes by Photon Interval Analysis
,Rev. Sci. Instrum,84:036105 2013
Takuhiro Otosu, Kunihiko Ishii and Tahei Tahara

Multiple Conformational State of Human Serum Albumin around Single Tryptophan Residue at Various pH Revealed by Time-resolved Fluorescence Spectroscopy
,Journal of Biochemistry,147:191-200 2010
Takuhiro Otosu, Etsuko Nishimoto, Shoji Yamashita

Fluorescence Decay Characteristics of Indole Compounds Revealed by Time-resolved Area-normalized Emission Spectroscopy
,Journal of Physical Chemistry A,113:2847-2853 2009
Takuhiro Otosu, Etsuko Nishimoto, Shoji Yamashita

Presentation
Leaflet-specific lipid diffusion of a supported lipid bilayer in the presence of cholesterol
第59回日本生物物理学会年会 211126
佐藤昌樹,坂口美幸,山口祥一,乙須拓洋

メタノール水溶液表面のヘテロダイン検出和周波発生分光
第15回分子科学討論会 210918
来須裕士,坂口美幸,乙須拓洋,山口祥一

同位体希釈水表面のヘテロダイン検出和周波発生分光
第15回分子科学討論会 210918
後藤悠希,坂口美幸,乙須拓洋,山口祥一

単層膜選択的拡散計測法による脂質物性の定量解析
第6回生体膜デザインコンファレンス 202401
乙須拓洋

The Effect of Polylysine Adsorption on the Leaflet-specific Lipid Diffusion in a Giant Unilamellar Vesicle
第61回日本生物物理学会年会 202311
清水光星,坂口美幸,山口祥一,乙須拓洋

Leaflet-specific lipid diffusion on ternary phase diagram of lipids studied by fluorescence lifetime correlation analyses
第61回日本生物物理学会年会 202311
乙須拓洋,坂口美幸,山口祥一

氷Ih,II,III,VI,VIIのラマン分光の実験と計算
第17回分子科学討論会 202309
大石梨恵,高山哲侑,乙須拓洋,山口祥一

Transferability of vibrational spectroscopic map from TIP4P to TIP4P-like water models
第38回化学反応討論会 202306
高山哲侑,乙須拓洋,山口祥一

Effect of Sucrose on the Diffusion of Proteins Tethered in a Glass-supported Lipid Bilayer
第57回日本生物物理学会年会 201909
針生弘光,乙須 拓洋,山口 祥一

Leaflet-specific Lipid Diffusions in Supported Lipid Bilayers
第57回日本生物物理学会年会 201909
乙須 拓洋,山口 祥一

カチオン性脂質が支持脂質二重膜中脂質の拡散特性に与える影響
第13回分子科学討論会 201909
乙須 拓洋,山口 祥一

二次元蛍光寿命相関分光法による支持脂質二重膜中脂質の拡散特性に関する研究
第12回分子科学討論会 201809
乙須 拓洋,山口 祥一

フルオレセインの酸塩基平衡に基づくタンパク質表面の微視的環境の研究
第7回CSJ化学フェスタ2017 201710
小林 海斗,乙須 拓洋,山口 祥一

全反射顕微鏡を用いた蛍光寿命相関分光法の開発と生体膜研究への応用
第11回分子科学討論会 201709
乙須 拓洋,山口 祥一

PEG 脂質を導入した支持脂質二重膜の拡散特性
第54回日本生物物理学会年会 201611
猿田萌子,乙須拓洋,山口祥一

新規蛍光相関分光法に基づく生体膜分子の拡散計測に向けた観測サイズ補正法の開発
第10回分子科学討論会 201609
乙須拓洋,山口祥一

Standing evanescent-wave fluorescence correlation spectroscopy for analyzing the translational diffusion in biomembranes
252th american chemical society national meeting & exhibition 201608
Takuhiro Otosu and Shoichi Yamaguchi

Translational diffusion in lipid membranes analyzed by standing evanescent-wave fluorescence correlation spectroscopy
32nd Symposium on Chemical Kinetics and Dynamics 201606
Takuhiro Otosu and Shoichi Yamaguchi

定在エバネッセント波を用いた蛍光相関分光装置の開発と脂質二重膜への応用
日本化学会第96春季年会 201603
乙須拓洋,山口祥一

蛍光分光法によるタンパク質‐脂質間相互作用の研究
日本化学会化学フェスタ 201020
塚原克浩,山口祥一,乙須拓洋

Raman Spectroscopy of Isotopically Pure and Diluted Low- and High-density Amorphous Ices
ACS Spring 2022
Senri Ishihara, Miyuki Sakaguchi, Takuhiro Otosu, Shoichi Yamaguchi

Development of a Diamond Anvil Cell Confocal Raman Microscope and its Application to High-pressure Phases of Ice and Clathrate Hydrate
ACS Spring 2022
Kota Kishi, Tatsuyuki Takayama, Miyuki Sakaguchi, Takuhiro Otosu, Shoichi Yamaguchi

Liposome Diffusion on a Glass-supported Lipid Bilayer
ACS Spring 2022
Ten Miyazaki, Miyuki Sakaguchi, Shoichi Yamaguchi, Takuhiro Otosu

氷Ⅵのラマン分光の実験と計算
第16回分子科学討論会
高山哲侑,坂口美幸,乙須拓洋,山口祥一

二次元蛍光寿命相関分光法によるDNA二重鎖形成ダイナミクスに与える分子混雑効果の解析
第16回分子科学討論会
三宅泰聖,坂口美幸,乙須拓洋,山口祥一

Fluorescence Lifetime Recovery After Photobleaching (FLRAP):Concept and application
第60回日本生物物理学会年会
森郁海,坂口美幸,山口祥一,乙須拓洋

モデル細胞膜中における糖脂質拡散の分光学的研究
第12回日本生物物理学会関東支部会
武藤拓泉,山口祥一,乙須拓洋

ポリリジン吸着による脂質膜物性変化の分光学的研究
第12回日本生物物理学会関東支部会
清水光星,山口祥一,乙須拓洋

シクロデキストリンによるモデル細胞膜からのコレステロール引き抜きの分光学的研究
第12回日本生物物理学会関東支部会
有浦滉平,山口祥一,乙須拓洋