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TSUKAHARA Shinji

Faculty: Graduate School of Science and Engineering TEL:
Position: Associate Professor ■FAX:
Address: 255 Shimo-Okubo, Sakura-ku, Saitama City, Saitama 338-8570, JAPAN ■Mail Address: stsuka@mail.saitama-u.ac.jp
■Web site:

Profile

Assigned Class

Brain Science Institute

Academic Background

Graduate School
(Doctor later) , 1999(Completed)
(Doctor prophase) , 1996(Completed)
College
1994(Graduated)
Degree

Awards

2010
2008
2008
2001

Research Career

Research Career
2005 - 2009 ,
2002 - 2004 ,
1999 - 2002 ,
1996 - 1999 ,
Other Career
2011 ,
2009 ,
2006 - 2009 ,

Research

Books, Articles, etc.

Books
哺乳類の性分化
西村書店,脳とホルモンの行動学—行動神経内分泌学への招待−:37-48 2010
塚原伸治

下位脳幹の性差
裳華房,脳の性分化:84-92 2006
塚原伸治

神経核形成のメカニズム(アポトーシス)
裳華房,脳の性分化:107-121 2006
塚原伸治、掛山正心

Articles
Differential mRNA expression of neuroimmune markers in the hippocampus of infant mice following toluene exposure during brain developmental period.
,Journal of Applied Toxicology:in press 2011
Tin-Tin-Win-Shwe, Kunugita N, Yoshida Y, Nakajima D, Tsukahara S, Fujimaki H

Effects of aromatase or estrogen receptor gene deletion on masculinization of the principal nucleus of the bed nucleus of the stria terminalis of mice.
,Neuroendocrinology:in press 2011
42. Tsukahara S, Tsuda M, Kurihara R, Kato Y, Kuroda Y, Nakata M, Xiao K, Nagata K, Toda K, Ogawa S

Does early life toluene exposure alter the expression of NMDA receptor subunits and signal transduction pathway in infant mouse hippocampus?
,Neurotoxicology,31(6):647-653 2010
Tin-Tin-Win-Shwe, Yoshida Y, Kunugita N, Tsukahara S, Fujimaki H

Intrauterine position affects estrogen receptor alpha expression in the ventromedial nucleus of the hypothalamus via promoter DNA methylation
,Endocrinology,151(12):5775-5781 2010
Mori H, Matsuda KI, Tsukahara S, Kawata M

The effect of D-cycloserine on spatial learning performance and memory function-related gene expression in mice following toluene exposure
,Journal of UOEH,32(2):127-140 2010
Win-Shwe TT, Kageyama S, Tsukahara S, Nakajima D, Fujimaki H

Up-regulation of neurotrophin-related gene expression in mouse hippocampus following low level toluene exposure
Elsevier,Neurotoxicology,31(1):85-93 2010
Win-Shwe TT, Tsukahara S, Yamamoto S, Fukushima A, KunugitaN, Arashidani K, Fujimaki H

Use of live imaging analysis for evaluation of cytotoxic chemicals that induce apoptotic cell death
,Toxicology In Vitro,24(7):2012-2020 2010
Koike-Kuroda Y, Kakeyama M, Fujimaki H, Tsukahara S

脳の性分化におよぼす発達期トルエン曝露の影響と作用機序
,室内環境,13(1):1-8 2010
塚原伸治、中島大介、藤巻秀和

Effects of maternal toluene exposure on testosterone levels in fetal rats
Elsevier,Toxicology Letters,185(2):79-84 2009
Tsukahara S, Nakajima D, Kuroda Y, Hojo R, Kageyama S, Fujimaki H

Measurement of toluene concentrations in the blood of fetuses of pregnant rats exposed to low concentration toluene using headspace solid phase micro extraction-gas chromatograph-mass spectrometry
日本薬学会,Journal of Health Science,55(1):50-55 2009
Nakajima D, Tsukahara S, Hojo R, Kageyama S, Goto S, Shiraishi H, Shiraishi F, Fujimaki H

Sex differences and roles of sex steroids in apoptosis of sexually dimorphic nuclei of preoptic area in postnatal rats
Blackwell,Journal of Neuroendocrinology,21(4):370-376 2009
Tsukahara S

ロードーシス神経制御機構の性差
中外医学社,Clinical Neuroscience,27(10):1120-1123 2009
山内兄人、塚原伸治

Estrogen modulates Bcl-2 family protein expression in the sexually dimorphic nucleus of the preoptic area of postnatal rats
,Neuroscience Letters,432(1):58-63 2008
Tsukahara S, Hojo R, Kuroda Y, Fujimaki H

オペラント学習法を用いたマウスのVOCガス検知閾値の計測
,におい・かおり環境学会誌,39(3):186-191 2008
北條理恵子、黒河佳香、塚原伸治、中島大介、藤巻秀和

揮発性有機化合物および農薬の発達期曝露による中枢神経系への影響についての調査研究
,大気環境学会誌,43(3):180-190 2008
塚原伸治、石堂正美、黒河佳香、藤巻秀和

胎児・小児への影響を考慮したVOC研究の現状と展開
,室内環境,11(2):103-109 2008
中島大介、塚原伸治、影山志保、白石不二雄、藤巻秀和

Activation of cholecystokinin neurons in the dorsal pallium of the telencephalon is indispensable for the acquisition of chick imprinting behavior
,Journal of Neurochemistry,102(5):1645-1657 2007
Maekawa F, Nakamori T, Uchimura M, Fujiwara K, Yada T, Tsukahara S, Kanamatsu T, Tanaka K, Ohki-Hamazaki H

Athymic nude mice are insensitive to low-level toluene-induced up-regulation of memory-related gene expressions in the hippocampus
,Neurotoxicology,28(5):957-964 2007
Win-Shwe TT, Tsukahara S, Ahamed S, Fukushima A, Yamamoto S, Kakeyama M, Nakajima D, Goto S, Kobayashi T, Fujimaki H

Effects of low-level formaldehyde exposure on synaptic plasticity related gene expression in the hippocampus of immunized mice
,Journal of Neuroimmunology,186(1-2):104-111 2007
Ahmed S, Tsukahara S, Win-Shwe TT, Yamamoto S, Kunugita N, Arashidani K, Fujimaki H

Increased hippocampal mRNA expression of neuronal synaptic plasticity related genes in mice chronically exposed to toluene at a low-level human occupational-exposure
,Neurotoxicology,28(1):168-174 2007
Ahmed S, Win-Shwe TT, Yamamoto S, Tsukahara S, Kunugita N, Arashidani K, Fujimaki H

Toluene induces rapid and reversible rise of hippocampal glutamate and taurine neurotransmitter levels in mice
,Toxicology Letters,168(1):75-82 2007
Win-Shwe TT, Mitsushima D, Nakajima D, Ahmed S, Yamamoto S, Tsukahara S, Kakeyama M, Goto S, Fujimaki H

Increased Fos immunoreactivity in suprachiasmatic nucleus before luteinizing hormone surge in estrogen-treated ovariectomized female rats
,Neuroendocrinology,83(5-6):303-312 2006
Tsukahara S

Inhalation of low-level formaldehyde increases the Bcl-2/Bax expression ratio in the hippocampus of immunologically sensitized mice
,Neuroimmunomodulation,13(2):63-68 2006
Tsukahara S, Yamamoto S, Tin-Tin-Win-Shwe, Ahmed S, Kunugita N, Arashidani K, Fujimaki H

Pituitary adenylate cyclase-activating polypeptide neurons of the ventromedial hypothalamus project to the midbrain central gray
,Neuroreport,17(2):221-224 2006
Maekawa F, Fujiwara K, Tsukahara S, Yada T

Progression of the dose-related effects of estrogenic endocrine disruptors, an important factor in declining fertility, differs between the hypothalamo-pituitary axis and reproductive organs of male mice
,Journal of Veterinary Medical Science,68(12):1257-1267 2006
Warita K, Sugawara T, Yue Z-P, Tsukahara S, Mutoh K, Hasegawa Y, Kitagawa H, Mori C, Hoshi N

Sex differences in the level of Bcl-2 family proteins and caspase-3 activation in the sexually dimorphic nuclei of the preoptic area in postnatal rats
,Journal of Neurobiology,66(13):1411-1419 2006
Tsukahara S, Kakeyama M, Toyofuku Y

Age-related change and its sex differences in histoarchitecture of the hypothalamic suprachiasmatic nucleus of F344/N rats
,Experimental Gerontology,40(3):147-155 2005
Tsukahara S, Tanaka S, Ishida K, Hoshi N, Kitagawa H

Presentation
マウス分界条床核主核の性差形成における芳香化アンドロゲンの役割
第63回日本動物学会関東支部大会 201103
栗原良平、津田夢芽子、チョウ・テッ・アウン、仲田真理子、大越幸太、戸田勝巳、小川園子、塚原伸治

脳の性分化機構:雌雄で異なる脳の構造と機能について
米沢バイオ公開セミナー・シンポジウム(最先端バイオ研究シンポジウム) 201103
塚原伸治

母仔マウスを用いた授乳期におけるトルエンの経路別曝露量解析
平成22年度室内環境学会学術大会 201012
中島大介、影山志保、Tin-Tin-Win-Shwe、河原純子、塚原伸治、藤巻秀和

Developmental neuroimmunotoxicity: changes in the expression of neuroimmune markers in the hippocampus of infant mice following early life toluene exposure
Neuro2010 201009
Tin-Tin Win-Shwe, Tsukahara S, Fujimaki H

nvolvement of postnatal apoptosis and effects of developmental chemical exposure on SDN-POA formation in rats
Neuro2010 201009
Shinji Tsukahara

げっ歯類における性的二型核の形成と性ステロイドの役割
日本動物学会第81回大会 201009
塚原伸治

Elimination of the morphological sex difference in the BNSTp of mice lacking the aromatase, estrogen receptor α (ERα), or ERβ gene
7th International Congress of Neuroendocrinology 201007
Tsukahara S, Tsuda M, Kato Y, Kuroda Y, Nakata M, Xiao K, Nagata K, Nakanishi T, Toda K, Ogawa S

ラット尿中クロルピリホス代謝物の経時変化
室内環境学会,平成21年度室内環境学会総会 200912
中島大介、鎌田亮、塚原伸治、渡邉清彦、高菅卓三、藤巻秀和、白石不二雄

Live imaging of sodium arsenite-induced apoptosis in PC12 cells
PPTOXII: Role of Environmental Stressors in the Developmental Origins of Disease 200912
Tsukahara S, Kuroda Y, Fujimaki H

ライブイメージング手法を用いた神経毒性試験法によるPC12細胞のアポトーシスに対する亜ヒ酸ナトリウムを曝露の影響解析
第32回日本神経科学大会 200909
塚原伸治、黒田淑子、藤巻秀和

臨界期におけるラット視床下部性的二型核でのタンパク質発現変化のプロテオミクス解析
第32回日本神経科学大会 200909
岩倉聖、塚原伸治、津田夢芽子、佐野一広、内村太一、小川園子、志賀隆、加藤智啓、大谷ー金子律子

子宮内環境による視床下部エストロゲン受容体αの発現量の制御
第32回日本神経科学大会 200909
森浩子、松田賢一、塚原伸治、河田光博

マウスの分界条床核の性差形成におけるエストロゲンの役割
第36回日本神経内分泌学会 200909
塚原伸治、渡井浩太、黒田淑子、加藤行則、仲田真理子、肖凱、津田夢芽子、戸田勝巳、小川園子

ライブイメージングと細胞の形態変化の定量的解析による新規神経毒性試験法の開発
第31回日本分子生物学会年会,第31回日本分子生物学会年会講演要旨集:836 200812
黒田淑子、塚原伸治、藤巻秀和

発達期のトルエン曝露によるテストステロン分泌および脳内のアポトーシス細胞死への影響
平成20年度室内環境学会総会,平成20年度室内環境学会総会講演集:164-165 200812
塚原伸治、黒田淑子、中島大介、影山志保、藤巻秀和

Effects of developmental exposure to toluene on the sexual differentiation of the brain
Japan/China Symposium 2008 (KIZUNA2008): Strategies to Reduce Risks on the Brain Development Contingent to Urbanization,Program and Abstracts:20 200810
Shinji Tsukahara

Effects of exposure to toluene on steroidogenesis in testes and sromatization of testosterone in brain of male rats furing fetal life
45th Congress of the European Societies of Toxicology,Toxicology Letters,180S:S42-43 200810
Tsukahara S, Nakajima D, Kuroda Y, Kageyama S, Hojo R & Fujimaki H

脳の性分化に関与する発達期の性ステロイドホルモン分泌および性的二型核のアポトーシスに及ぼすトルエン曝露の影響
第49回大気環境学会年会,第49回大気環境学会年会講演要旨集:433 200809
塚原伸治、中島大介、黒田淑子、影山志保、藤巻秀和

Sex difference in apoptosis and role of estrogen in the sexually dimorphic nucleus of the preoptic area (SDN-POA) in postnatal rats
US/Japan Neurosteroid Symposium 2008,Program and Abstracts:S26 200809
Shinji Tsukahara

日本神経内分泌学会川上賞受賞講演:発達期の性的二型核におけるアポトーシスに関する研究
第35回日本神経内分泌学会・第23回日本下垂体研究会合同学術集会,第35回日本神経内分泌学会・第23回日本下垂体研究会合同学術集会抄録集:39 200808
塚原伸治

周産期トルエン曝露による胎仔ラットの脳内エストラジオール含量および出生仔ラットのSDN-POAのアポトーシスへの影響
第31回日本神経科学大会,Neuroscience Research,61:S108 200807
塚原伸治、中島大介、黒田淑子、影山志保、藤巻秀和