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MATSUOKA Koji

Faculty: Graduate School of Science and Engineering TEL:
Position: Professor/Director ■FAX:
Address: 255 Shimo-okubo, Sakura, Saitama 338-8570, Japan ■Mail Address: koji@fms.saitama-u.ac.jp
■Web site: http://md.fms.saitama-u.ac.jp

Profile

Assigned Class

School of Engineering
Open Innovation Center/Advanced Institute of Innovative Technology

Research Field

Bioorganic chemistry
Synthetic chemistry
Polymer synthesis
Glycotechnology
keyword:Glycoconjugates , Organic Chemistry , Synthetic Chemistry , Biochemistry , Polymer Chemistry , Glycoclusters , Glycodendrimers , Glycopolymers , Biopolymers , Bioactive Natural Products

Academic Societies

Academic Societies
Japanese society of carbohydrate research,
FCCA
The american chemical society,
Chemical society of Japan
Society of polymer science, Japan
Society of synthetic organic chemistry, Japan

Academic Background

Graduate School
Hokkaido university , (Doctor later , Division of Biological sciences , Graduate school of science) , 1995(Completed)
Seikei university , (Doctor prophase , Department of industrial chemistry , Graduate school of Engineering) , 1992(Completed)
College
Seikei university , (Department of industrial chemistry , Faculty of enginieering) , 1990(Graduated)
Degree
Dr. (Science) , Hokkaido university , Syntheses and Biochemical Evaluation of Novel Glycoligands
Ms. (Engineering) , Seikei university

Research

Books, Articles, etc.

Books
ノイラミニダーゼ阻害剤の合成研究
シー・エム・シー出版,複合糖質の化学と最新応用技術:270-277 200906
松岡浩司、幡野健、照沼大陽

糖鎖デンドリマー
エヌ・ティー・エス出版,超分子サイエンス:1043-1048 200905
松岡浩司、幡野健、照沼大陽

Sugar Polymers (Dendrimers and Pendant-type Linear Polymers)
Springer,Experimental Glycoscience:206-209 2008
K. Matsuoka, N. Taniguchi, A. Suzuki, Y. Ito, H. Narimatsu, T. Kawasaki, and S. Hase, (Eds.)

Glycodendrimers using carbosilanes as core scaffolds (Review)
Transworld Research Network,Nanotechnology in Carbohydrate Chemistry:89-102 2006
K. Matsuoka, K. Hatano, and D. Terunuma, H. Yuasa (Ed)

グライコデンドリマー
エヌ・ティー・エス出版,糖鎖科学の新展開:483-491 2005
松岡浩司, 幡野健, 森知紀, 照沼大陽

機能性デンドリマーの合成
シーエムシー出版,糖鎖化学の最先端技術:225-235 2005
松岡浩司, 幡野健, 照沼大陽

糖鎖高分子 (デンドリマー, グライコマテリアル)
金芳堂,未来を拓く糖鎖科学:123-125 2005
松岡浩司

カルボシランデンドリマー-糖鎖複合物質--大腸菌O157の産生するベロ毒素中和剤の開発--
シーエムシー出版,21世紀の有機ケイ素化学:258-264 2004
照沼大陽, 松岡浩司, 幡野健

Preparation of Fluorescence-Labeled Neoglycolipids for Ceramide Glycanase Assays
Academic Preess,Methods in Enzymol.,278:519-528 1997
K. Matsuoka, S.-I. Nishimura, and Y. C. Lee

Articles
Synthesis of 3-Phenyldibenzo[b,d]furan-type Bioprobes Utilizing Vialinin B as a Structural Motif
Taylor & Francis Inc.,Synthetic Commun.,47:22-28 2017
S. Takahashi*, Y. Suda, T. Nakamura, K. Matsuoka, and H. Koshino

Synthetic Assembly of Mannose Moieties using Polymer Chemistry and the Biological Evaluation of its Interaction towards Concanavalin A
MDPI AG,Molecules,22:157 2017
D. Diwan, K. Shinkai, T. Tetsuka, B. Cao, H. Arai, T. Koyama, K. Hatano, and K. Matsuoka*

Total Synthesis of Kehokorins A−E, Cytotoxic p-Terphenyls
AMER CHEMICAL SOC,J. Org. Chem.,82:3159-3166 2017
S. Takahashi*, Y. Suda, T. Nakamura, K. Matsuoka, and H. Koshino

DNA-based Mutation Assay (GPMA): Reproducibility, ppb-order Sensitivity, and Introduction of a Mammalian Cell-based Approach
OXFORD UNIV PRESS,J. Biohem.,162:395-401 2017
P. Kumari, S. G. Gautam, M. Baba, M. Tsukiashi, K. Matsuoka, K. Yasukawa, and K. Nishigaki*

Iodoacetyl-functionalized Pullulan: a Supplemental Enhancer for Single-domain Antibody–Polyclonal Antibody Sandwich Enzyme-linked Immunosorbent Assay for Detection of Survivin
PERGAMON-ELSEVIER SCIENCE LTD,Bioorg. Med. Chem. Lett.,27:4844-4848 2017
T. Matsushita, H. Arai, T. Koyama, K. Hatano, N. Nemoto, and K. Matsuoka*

Synthetic Assembly of Novel Avidin-biotin-GlcNAc (ABG) Complex as an Attractive Bio-probe and its Interaction with Wheat Germ Agglutinin (WGA)
Elsevier,Bioorg. Chem.,68:219-225 2016
A. Kumari, T. Koyama, K. Hatano and K. Matsuoka

Synthesis of Fluorinated Polymers and Evaluation of Wettability
MDPI AG,Molecules,21:358 2016
T. Kimura, Maria C.Z. Kasuya, K. Hatanaka, and K. Matsuoka

Biological Evaluation of Multivalent-Type N-Acetyl-D-Glucosamine (GlcNAc) Conjugates for Wheat Germ Agglutinin (WGA) by the Surface Plasmon Resonance (SPR) Method
Symbiosis,SOJ Biochemistry,2:7 2016
A. Kumari, T. Koyama, K. Hatano, and K. Matsuoka
Analysis of the interaction of synthetic avidin-biotin-GlcNAc (ABG) glycocluster complex with a well-known lectin, wheat germ agglutinin (WGA), was performed with a biosensor based on surface plasmon resonance (SPR). In the SPR measurements, WGA was covalently coupled to the gold surface using the amine-coupling method. Artificial glycopolymers of N-acetyl-Dglucosamine, polystyrene-based linear-type glycoclusters with a polymeric backbone of acrylamide, were used as controls. Three glycopolymers, including tetrameric ABG complex, glycopolymer 1 with a monomer and acrylamide ratio of 1:10 and glycopolymer 2 with a ratio of 1:4, were used as analytes. The SPR method was used for the analysis of the interactions that covered a high affinity range; namely, the strong binding of KA ~ 6.45 x 10^7 M^(-1) for ABG compared with glycopolymers 1 and 2, which show binding of KA ~ 3.41 x 10^5 M^(-1) and KA ~ 3.30 x 10^5 M^(-1) respectively. SPR measurements confirmed that WGA has higher affinity toward the tetrameric ABG complex than toward the linear-type glycopolymers 1 and 2, and the usefulness of these synthetic glycopolymers as tools in the study of sugar-lectin interactions has been proved due to the very well-known “glycocluster effect”.
Surface plasmon resonance; Glycocluster effect; Polystyrene; Analyte; Amine coupling; Multivalent

L-Fucose-containing Arabinogalactan-protein in Radish Leaves
ELSEVIER SCI LTD,Carbohydr. Res.,415:1-11 2015
M. Inaba, T. Maruyama, Y. Yoshimi, T. Kotake, K. Matsuoka, T. Koyama, T. Tryfona, P. Dupree, and Y. Tsumuraya

Effect of Aglycon Structure on Saccharide Elongation by Cells
WILEY-V C H VERLAG GMBH,Chem. Biodiv.,12:239-247 2015
T. Kimura, Maria C.Z. Kasuya, K. Hatanaka*, and K. Matsuoka

Enzymatic Fragmentation of Carbohydrate Moieties of Radish Arabinogalactan-protein and Elucidation of the Structures
TAYLOR & FRANCIS LTD,,Biosci. Biotechnol. Biochem.,78(5):818-831 2014
R. Shimoda, K. Okabe, T. Kotake, K. Matsuoka, T. Koyama, T. Tryfona, H.-C. Liang, P. Dupree, Y. Tsumuraya*
alpha-L-arabinofuranosidase; arabinogalactan-protein; L-arabino-galactooligosaccharide; exo-beta-(1 -> 3)-galactanase, radish

Use of Chloromethylstyrene as A Supporter for Convenient Preparation of Carbohydrate Monomer and Glycopolymers
ELSEVIER SCI LTD,Carbohydr. Polym.,107:209-213 2014
K. Matsuoka*, A. Kurita, T. Koyama, and K. Hatano
Styrene; Glycopolymers; Radical polymerization; Lectins; Fluorescence spectrometry

Synthesis of Chiral Dopants based on Carbohydrates
ELSEVIER SCI LTD,Carbohydr. Res.,393:15-22 2014
T. Tsuruta, M. Yasutake, T. Koyama, K. Hatano, and K. Matsuoka*

Structural Revision of Kynapcin-12 by Total Synthesis, and Inhibitory Activities against Prolyl Oligopeptidase and Cancer Cells
PERGAMON-ELSEVIER SCIENCE LTD,Bioorg. Med. Chem. Lett.,24:3373-3376 2014
S. Takahashi*, A. Yoshida, S. Uesugi, Y. Hongo, K.-i. Kimura, K. Matsuoka, and H. Koshino

Synthesis and Structural Revision of a Brominated Sesquiterpenoid, Aldingenin C
AMER CHEMICAL SOC,J. Org. Chem.,79:9373–9380 2014
S. Takahashi*, M. Yasuda, T. Nakamura, K. Hatano, K. Matsuoka, and H. Koshino

Synthesis and Influenza Virus Inhibitory Activities of Carbosilane Dendrimers Peripherally Functionalized with Hemagglutinin-Binding Peptide
AMER CHEMICAL S,J. Med. Chem.,57:8332-8339 2014
K. Hatano*, T. Matsubara, Y. Muramatsu, M. Ezure, T. Koyama, K. Matsuoka, R. Kuriyama, H. Kori, and T. Sato

基質の活性向上を目指し、高分子化によるクラスター効果の発現や発光特性改変の探索
,TAMA 大学技術工房70,3:24 2013
松岡浩司

Inhibitory Effects and Specificity of Synthetic Sialyldendrimers toward Recombinant Human Neuraminidase 2 (NEU2)
OXFORD UNIV PRESS INC,Glycobiology,23:495-504 2013
M. M. Rahman, S. Kitao, D. Tsuji, K. Suzuki, J.-I. Sakamoto, K. Matsuoka, F. Matsuzawa, S.-I. Aikawa, and K. Itoh
docking model; inhibitor; sialidase 2; sialyldendrimers; thiosialyloligosaccharides

Carbohydrate Immobilized on a Dendrimer-Coated Colloidal Gold Surface for Fabrication of a Lectin-Sensing Device Based on Localized Surface Plasmon Resonance Spectroscopy
Elsevier,Biosensors & Bioelectronics,41:465-470 2013
M. Ogiso, J. Kobayashi, T. Imai, K. Matsuoka, M. Itoh, T. Imamura, T. Okada, H. Miura, T. Nishiyama, T. Matsuda, T. Hirahashi, S. Fujieda, N. Minoura, and K. Hatanaka
Localized surface plasmon resonance (LSPR); Glycan array; Biosensor; Polyamidoamine dendrimer; Lectin

Structural Revision of Pochonicine and Determination of its Absolute Configuration by Chemical Synthesis
Elsevier,Tetrahedron Lett.,54:1456-1459 2013
Y. Kitamura, H. Koshino, T. Nakamura, A. Tsuchida, T. Nitoda, H. Kanzaki, K. Matsuoka, and S. Takahashi
Pochonicine; GIcNAcase inhibitor; N-Acetyl-D-glucosamine; D-Allopyranoside

Immobilization of Carbohydrate Clusters on a Quartz Crystal Microbalance Sensor Surface
Elsevier,J. Colloid Interfce Sci.,393:257-263 2013
M. Ogiso, K. Matsuoka, T. Okada, T. Imai, M. Itoh, T. Imamura, Y. Haga, K. Hatanaka, and N. Minoura
Quartz crystal microbalance (QCM); Polyamidoamine dendrimer; Ganglioside; Wheat germ agglutinin (WGA)

Carbosilane Glycodendrimers (Review)
ROYAL SOC CHEMISTRY,Chem. Soc. Rev.,42:4574-4598 2013
K. Hatano, K. Matsuoka, and D. Terunuma
INFLUENZA NEURAMINIDASE INHIBITORS; DENDRIMER CORE SCAFFOLDS; SHIGA-LIKE TOXIN; ONE-POT REACTION; PERIPHERAL GLOBOTRIAOSE; BINDING ACTIVITIES; BIRCH REDUCTION; LIQUID-AMMONIA; MOIETIES; LACTOSE

A Novel Method for the Production of Sialylparagloboside
Elsevier,Helv. Chim. Acta,95:67-75 201201
Y. Shimura, J. Suzuki, M. C. Z. Kasuya, K. Matsuoka, and K. Hatanaka

Synthetic Assembly of Bi-Fluorescence-Labeled Glycopolymers as Substrates for Assaying α-Amylase by Resonance Energy Transfer
American Chemical Sciety,ACS Macro Lett.,1:266-269 201201
K. Matsuoka, H. Arai, H. Oka, T. Koyama, and K. Hatano

Synthetic Studies of Bi-fluorescence-labeled Maltooligosaccharides as Substrates for α-Amylase on the Basis of Fluorescence Resonance Energy Transfer (FRET)
Elsevier,Bioorg. Med. Chem.,20:435-445 201201
H. Oka, T. Koyama, K. Hatano, and K. Matsuoka

Synthesis and Biological Evaluation of Sialic Acid Derivatives Containing a Long Hydrophobic Chain at the Anomeric Position and Their C-5 Linked Polymers as Potent Influenza Virus Inhibitors
Elsevier,Bioorg. Med. Chem.,20:446-454 201201
K. Suzuki, T. Koyama, S. Yingsakmongkon, Y. Suzuki, K. Hatano, and K. Matsuoka

Intricate Recognition of Glycolipid-like Compounds by HIV-1 Envelope Proteins Evaluated with Surface Plasmon Resonance Imaging
TAYLOR & FRANCIS INC,J. Carbohydr. Chem.,31:584-592 2012
T. Okada, A. Kimura, H. Miura, T. Nishiyama, M. Mori, J. Suzuki, M. Ogiso, K. Matsuoka, T. Sato, K. Hatanaka, and N. Minoura

Influence of Passage Number on Glycosylation of Alkyl Lactosides by MDCK Cells
SOC BIOSCIENCE BIOENGINEERING JAPAN,J. Biosci. Bioengin.,114:552-555 2012
Y. Shimura, J. Suzuki, M. C. Z. Kasuya, K. Matsuoka, and K. Hatanaka

Convenient Assembly of Trimeric LeX Determinants using Carbosilane Scaffolds by means of Huisgen Cycloaddition
Elsevier,Tetrahedron Lett.,53:6793-6796 2012
K. Matsuoka, H. Yamaguchi, T. Kohzu, J.-I. Sakamoto, T. Koyama, K. Hatano, S. Yamamoto, T. Mori, and K. Hatanaka

Glyco-silicon Functional Materials as Anti-influenza Virus Agents (Review)
Bentham Science Publishers,Open Glycosience,5:31-40 2012
K. Matsuoka, T. Koyama, and K. Hatano

Lectin Detection Based on the Aggregation-induced Emission Eeffect (Review)
GAKUSHIN PUBL CO,Trends in Glycosci. Glycotech.,28:78-94 2012
K. Hatano, K. Matsuoka, and D. Terunuma

A Carbosilane Dendrimer and a Silacyclopentadiene Analog Carrying Peripheral Lactoses as Drug-delivery Systems
Elsevier,Bioorg. Med. Chem. Lett.,22:3564-3566 2012
H. Aizawa, K. Otomo, N. Honsho, T. Shimazaki, M. Villeneuve, K. Matsuoka, K. Hatano, and D. Terunuma

Large Scale Biosynthesis of Ganglioside Analogues by RERF-LC-AI Cells Cultured in HYPERFlask
TAYLOR & FRANCIS INC,Prep. Biochem. Biotech.,42:378-392 2012
Y. Shimura, J. Suzuki, M. Muraoka, M. C. Z. Kasuya, K. Matsuoka, and K. Hatanaka

Synthesis of Sialyllactosamine Clusters using Carbosilane as Core Scaffolds by means of Chemical and Enzymatic Approaches
Elsevier,Bioorg. Med. Chem. Lett.,20:4906-4910 2010
K. Matsuoka, R. Kaneko, T. Koyama, X.-T. Ma, Y. Esumi, T. Nakamura, K. Hatano, and D. Terunuma

Synthetic Construction of a Fucosyl Chitobiose as an Allergen-associated Carbohydrate Epitope and the Glycopolymer Involving Highly Clustered Trisaccharidic Sequences
Elsevier,Tetrahedron Lett.,51:2529-2532 2010
K. Matsuoka, H. Yamaguchi, T. Koyama, K. Hatano, and D. Terunuma

Simple and Conveniently Accessible Bi-fluorescence-labeled Substrates for Amylases
Elsevier,Bioorg. Med. Chem. Lett.,20:1969-1971 2010
H. Oka, T. Koyama, K. Hatano, D. Terunuma, and K. Matsuoka

Analytical Investigations of the Behavior of Silole-core Dendrimers with Peripheral Globotriaose in Water and Acetone/Water Mixed Solvent
Elsevier,Tetrahedron Lett.,51:1545-1549 2010
H. Aizawa, K. Hatano, H. Saeki, N. Honsho, T. Koyama, K. Matsuoka, and D. Terunuma

Synthesis and Characterization of Photo-responsive Carbosilane Dendrimers
Molecular Diversity Preservation International,Molecules,14(6):2226-2234 200906
T.Koyama, K.Hatano, K.Matsuoka, Y.Esumi, and D.Terunuma

Bifunctional Cytosolic UDP-Glucose 4-Epimerases Catalyze the Interconversion between UDP-D-Xylose and UDP-L-Arabinose in Plants
Biochemical Society,Biochem. J.,424(2):169-177 2009
T.Kotake, R.Takata, R.Verma, M.Takaba, D.Yamaguchi, T.Orita, S.Kaneko, K.Matsuoka, T.Koyama, W.-D.Reiter, and Y.Tsumuraya

Systematic Syntheses of Influenza Neuraminidase Inhibitors: a Series of Carbosilane Dendrimers Uniformly Functionalized with Thioglycoside-type Sialic Acid Moieties
Elsevier,Bioorg. Med. Chem.,17(15):5451-5464 2009
J.I.Sakamoto, T.Koyama, D.Miyamoto, S.Yingsakmongkon, K.I.P.J.Hidari, W.Jampangern, T.Suzuki, Y.Suzuki, Y.Esumi, T.Nakamura, K.Hatano, D.Terunuma, and K.Matsuoka

Syntheses and Biological Evaluations of Carbosilane Dendrimers Uniformly Functionalized with Sialyl alpha(2-3) Lactose Moieties as Inhibitors for Human Influenza Viruses
Elsevier,Bioorg. Med. Chem.,17(15):5465-5475 2009
H.Oka, T.Onaga, T.Koyama, C.-T.Guo, Y.Suzuki, Y.Esumi, K.Hatano, D.Terunuma, and K.Matsuoka

Synthetic Construction of a Lex Determinant via Gabriel Amine Synthesis and the Glycopolymer Involving Highly Clustered Lex Residues
Elsevier,Tetrahedron Lett.,50(21):2593-2596 2009
K.Matsuoka, T.Kohzu, T.Hakumura, T.Koyama, K.Hatano, and D.Terunuma

Synthesis of Sialic Acid Derivatives Having a C=C Double Bond Substituted at the C-5 Position and Their Glycopolymers
Elsevier,Bioorg. Med. Chem. Lett.,19(17):5105-5108 2009
K.Suzuki, J.-I.Sakamoto, T.Koyama, S.Yingsakmongkon, Y.Suzuki, K.Hatano, D.Terunuma, and K.Matsuoka

Relapsing Fever Borrelia Binds to Neolacto Glycans and Mediates Rosetting of Human Erythrocytes
National Academy of Sciences,Proc. Natl. Acad. Sci. USA,106(46):19280-19285 2009
B.P.Guo, S.Teneberg, R.M nch, D.Terunuma, K.Hatano, K.Matsuoka, J.Ångstr m, T.Bor n, and S.Bergstr m

Fluorescence Quenching Detection of Peanut Agglutinin Based on Photoluminescent Silole-core Carbosilane Dendrimer Peripherally Functionalized with Lactose
Elsevier,Tetrahedron Lett.,50(42):5816-5819 2009
K.Hatano, H.Saeki, H.Yokota, H.Aizawa, T.Koyama, K.Matsuoka, and D.Terunuma

タミフル耐性インフルエンザウィルス阻害剤の基礎研究 (II)
埼玉大学総合研究機構,総合研究機構研究プロジェクト研究成果報告書(6(平成19年度)) 200809
松岡 浩司
Study of inhibitors for Tamiflu®-resistant influenza virus (II)

A bifunctional enzyme with L-fucokinase and GDP-L-fucose pyrophosphorylase activities salvages free L-fucose in Arabidopsis
American Society for Biochemistry and Molecular Biology,J. Biol. Chem.,283(13):8125-8135 2008
T. Kotake, S. Hojo, N.i Tajima, K. Matsuoka, T. Koyama, and Y. Tsumuraya

Properties of family 79 beta-glucuronidases that hydrolyze beta-glucuronosyl and 4-O-methyl-beta-glucuronosyl residues of arabinogalactan-protein
Elsevier,Carbohydr. Res.,343(7):1191-1201 2008
T. Konishi, T. Kotake, D. Soraya, K. Matsuoka, T. Koyama, S. Kaneko, K. Igarashi, M. Samejima, and Y. Tsumuraya

Sialyl alpha(2 -> 3) lactose clusters using carbosilane dendrimer core scaffolds as influenza hemagglutinin blockers
Elsevier,Bioorg. Med. Chem. Lett.,18(15):4405-4408 2008
H. Oka, T. Onaga, T. Koyama, C.-T. Guo, Y. Suzuki, Y. Esumi, K. Hatano, D. Terunuma, and K. Matsuoka

Synthesis and Lectin-binding Activity of Luminescent Silica Particles Peripherally Functionalized with Lactose
Elsevier,Tetrahedron Lett.,49(39):5593-5596 2008
K. Hatano, T. Yamazaki, K. Yoshino, N. Ohyama, T. Koyama, K. Matsuoka, and D. Terunuma

Use of a recycle-type SEC method as a powerful tool for purification of thiosialoside derivatives
Elsevier,Carbohydr. Res.,343(16):2735-2739 2008
J.-I. Sakamoto, C. Takita, T. Koyama, K. Hatano, D. Terunuma, and K. Matsuoka

糖鎖と有機ケイ素化合物の複合による新規機能材料
,化学工業,59(2):95-100 2008
幡野健, 松岡浩司, 照沼大陽

標的認識能を有する有機ケイ素-糖鎖ハイブリッド材料
,未来材料,8:45-50 2008
照沼大陽, 松岡浩司, 幡野健

Highly-luminescent Glycocluster: Silole-core Carbosilane Dendrimer Having Peripheral Globotriaose
Elsevier,Tetrahedron Lett.,48(25):4365-4368 2007
K. Hatano, H. Aizawa, H. Yokota, A. Yamada, Y. Esumi, H. Koshino, T. Koyama, K. Matsuoka, and D. Terunuma

Lactotriaose-containing carbosilane dendrimers: syntheses and lectin-binding activities
Elsevier,Bioorg. Med. Chem.,15(4):1606-1614 2007
A. Yamada, K. Hatano, T. Koyama, K. Matsuoka, N. Takahashi, K.I.P.J. Hidari, Y. Suzuki, and D. Terunuma

Novel Linear Polymers Bearing Thiosialosides as Pendant-type Epitopes for Influenza Neuraminidase Inhibitors
Elsevier,Bioorg. Med. Chem. Lett.,17(14):3826-3830 2007
K. Matsuoka, C. Takita, T. Koyama, D. Miyamoto, S. Yingsakmongkon, K. I.P.J. Hidari, W. Jampangern, T. Suzuki, Y. Suzuki, K. Hatano, and D. Terunuma

Practical Synthesis of Fully Protected Globotriaose and Its Glycopolymers
Elsevier,Carbohydr. Polym.,69(2):326-335 2007
K. Matsuoka, Y. Goshu, Y. Takezawa, T. Mori, J.-I. Sakamoto, A. Yamada, T. Onaga, T. Koyama, K. Hatano, P. W. Snyder, E. J. Toone, and D. Terunuma

Site-Specific, Covalent Attachment of Poly(dT)-Modified Peptides To Solid Surfaces for Microarrays
American Chemical Society,Bioconjugate Chem.,18(6):1778-1785 2007
N. Kimura, T. Okegawa, K. Yamazaki, and K. Matsuoka

Thiosialoside Clusters Using Carbosilane Dendrimer Core Scaffolds as a New Class of Influenza Neuraminidase Inhibitors
Elsevier,Bioorg. Med. Chem. Lett.,17(3):717-721 2007
J.-I. Sakamoto, T. Koyama, D. Miyamoto, S. Yingsakmongkon, K.I.P.J. Hidari, W. Jampangern, T. Suzuki, Y. Suzuki, Y. Esumi, K. Hatano, D. Terunuma, and K. Matsuoka

Design, Synthesis, and Biological Evaluation of Glyco-Materials
,8th International Symposium on Biotechnology, Metal complexes and Catalysis:24-25 200611
K. Matsuoka

Carbosilane Dendrimers Bearing Globotriaoses: Construction of A Series of Carbosilane Dendrimers Bearing Globotriaoses
American Chemical Sciety,Biomacromolecules,7(8):2284-2290 2006
K. Matsuoka, M. Terabatake, Y. Esumi, K. Hatano, D. Terunuma, and H. Kuzuhara

Carbosilane Dendrimers Bearing Globotriaoses: Syntheses of Globotrioasyl Derivative and Introduction into Carbosilane Dendrimers
American Chemical Sciety,Biomacromolecules,7(8):2274-2283 2006
K. Matsuoka, M. Terabatake, A. Umino, Y. Esumi, K. Hatano, D. Terunuma, and H. Kuzuhara

Identification and Characterization of Carbohydrate Molecules in Mammalian Cells Recognized by Dengue Virus Type 2
Oxford University Press,J. Biochem.,139(3):607-614 2006
C. Aoki, K.I.P.J. Hidari, S. Itonori, A. Yamada, N. Takahashi, T. Kasama, F. Hasebe, M.A. Islam, K. Hatano, K. Matsuoka, T. Taki, C.-T. Guo, T. Takahashi, Y. Sakano, T. Suzuki, D. Miyamoto, M. Sugita, D. Terunuma, K. Morita, and Y. Suzuki

Structural Analysis of the Interaction between Shiga Toxin B Subunits and Linear Polymers Bearing Clustered Globotriose Residues
American Society for Microbiology,Infect. Immun.,74(3):1984-1988 2006
M. Watanabe, K. Igai, K. Matsuoka, A. Miyagawa, T. Watanabe, R. Yanoshita, Y. Samejima, D. Terunuma, Y. Natori, and K. Nishikawa

Syntheses and Vero Toxin-binding Activities of Carbosilane Dendrimers Periphery-functionalized with Galabiose
Elsevier,Tetrahedron,62(21):5074-5083 2006
A. Yamada, K. Hatano, K. Matsuoka, T. Koyama, Y. Esumi, H. Koshino, K. Hino, K. Nishikawa, Y. Natori, and D. Terunuma

Syntheses of a Series of Lacto-N-neotetraose Clusters using a Carbosilane Dendrimer Scaffold
Elsevier,Carbohydr. Res.,341(4):467-473 2006
A. Yamada, K. Hatano, T. Koyama, K. Matsuoka, Y. Esumi, and Daiyo Terunuma

Synthesis of a Series of Carbosilane Dendrimers Having Thioglycoside-type Sialic Acid Moieties
International Carbohydrate Organization,XXIIIrd International Carbohydrate Symposium:279 2006
J.-I. Sakamoto, T. Koyama, Y. Esumi, H. Koshino, K. I.-P. J. Hidari, T. Suzuki, Y. Suzuki, K. Hatano, D. Terunuma, and K. Matsuoka

Synthetic Construction of Novel Sugar―Amino Acid Hybrid Materials Using Typical Radical Polymerization Protocol
International Carbohydrate Organization,XXIIIrd International Carbohydrate Symposium:275 2006
K. Matsuoka, Y. Goshu, T. Koyama, K. Hatano, and D. Terunuma

Thiosialoside Clusters as Inhibitors for Influenza Virus Neuraminidases
,22nd International Symposium on the Organic Chemistry of Sulfur:173 2006
J.-I. Sakamoto, C. Takita, T. Koyama, K. Hatano, D. Terunuma, Y. Esumi, K. I.-P. J. Hidari, S. Yingsakmongkon, D. Miyamoto, W. Usawattanakul, T. Suzuki, Y. Suzuki, and K. Matsuoka

Advantages of Carbosilane Dendrimer as a Carbohydrate Scaffold --Application to Artificial Receptor of E. Coli, Influenza and Dengue Virus--
,The 14th International Symposium on Organosilicon Chemistry:78 2005
Ken Hatano, Akihiro Yamada, Tetsuo Koyama, Koji Matsuoka, Daiyo Terunuma, Yasuaki Esumi, Kiyotaka Nishikawa, Yasuhiro Natori, Kazuya Hidari and Yasuo Suzuki

Identification of the Optimal Structure Required for a Shiga Toxin Neutralizer with Oriented Carbohydrates to Function in the Circulation
University of Chicago Press,J. Infect. Dis.,191(12):2097-2105 2005
K. Nishikawa, K. Matsuoka, M. Watanabe, K. Igai, K. Hino, K. Hatano, A. Yamada, N. Abe, D. Terunuma, H. Kuzuhara, and Y. Natori

Syntheses and Biological Assay of a Series of Lacto-N-neotetraose Cluster using Carbosilane Dendrimer Scaffolds
,The 14th International Symposium on Organosilicon Chemistry:134 2005
Akihiro, Yamada, Ken Hatano, Koji Matsuoka, Yasuaki Esumi, Chie Aoki, Kazuya Hidari, Yasuo Suzuki and Daiyo Terunuma

Synthesis of Carbosilane Dendrimers Having Peripheral Mannose and Mannobiose
Elsevier,Tetrahedron,61(11):2751-2760 2005
T. Mori, K. Hatano, K. Matsuoka, Y. Esumi, E. J. Toone, and D. Terunuma

グロボ三糖担持カルボシランデンドリマーの合成 -カルボシランデンドリマー構造がO157:H7が産生するベロ毒素の阻害活性に及ぼす効果- (Review)
有機化学合成協会,有機合成化学協会誌,63(7):722-727 2005
照沼大陽, 松岡浩司, 幡野健
Syntheses of Carbosilane Dendrimers Carrying Peripheral Globotriaose Derivatives -The Relationship between the Carbosilane Dendrimer Structure and the Magnitude for Neutralizing Shiga toxin-producing Escherichia coli O157:H7-, J. Syn. Org. Chem. Jpn.

Synthesis of a Useful Lauryl Thioglycoside of Sialic Acid and its Application
Elsevier,Tetrahedron Lett.,45(51):9383-9386 200412
K. Matsuoka, T. Onaga, T. Mori, J.-I. Sakamoto, T. Koyama, N. Sakairi, K. Hatano, and D. Terunuma

Synthesis of Glycoconjugate Polymer Carrying Globotriaose as Artificial Multivalent Ligand for Shiga Toxin-producing Escherichia coli O157: H7
Elsevier,Carbohydr. Polym.,57(4):441-450 200409
A. Miyagawa, H. Kurosawa, T. Watanabe, T. Koyama, D. Terunuma, and K. Matsuoka

シクロデキストリンの化学修飾(ミニレビュー)
日本農芸化学会,日本農芸化学会誌,78(9):863-865 200409
松岡浩司
Chemical Modification of Cyclodextrins (Mini Review), Nippon Nogeikagaku Kaishi

Oral Therapeutic Agents with Highly Clustered Globotriose for Treatment of Shiga Toxigenic Escherichia coli Infections
University of Chicago Press,J. Infect. Dis.,189(3):360-368 2004
M. Watanabe, K. Matsuoka, E. Kita, K. Igai, N. Higashi, A. Miyagawa, T. Watanabe, R. Yanoshita, Y. Samejima, D. Terunuma, Y. Natori, and K. Nishikawa

Synthesis and Biological Evaluation of Glycopolymer as Shiga Toxin Neutralizer
Oxford University Press,Glycobiology,14:1194 2004
K. Matsuoka, A. Miyagawa, K. Nishikawa, M. Watanabe, Y. Natori, E. Kita, T. Koyama, K. Hatano, and D. Terunuma

Synthesis and Property of Carbosilane Dendrimers Functionalizing Peripheral Mannose Moieties
Oxford University Press,Glycobiology,14:1093 2004
T. Mori, K. Hatano, K. Matsuoka, Y. Esumi, E. J. Toone, and D. Terunuma

化学合成と酵素合成によるN-アセチルラクトサミンクラスターの構築
,埼玉大学地域共同研究センター紀要,4:86 2004
松岡浩司、照沼大陽

Synthesis of a Useful Anomeric Thioacetate of an N-Acetyllactosamine Derivative and its Application
Elsevier,Tetrahedron Lett.,44(18):3617-3620 2003
K. Matsuoka, T. Ohtawa, H. Hinou, T. Koyama, Y. Esumi, S.-I. Nishimura, K. Hatano, and D. Terunuma

新規カルボシランデンドリマーの合成とその構造が液晶性に与える効果
高分子学会,高分子論文集,60(10):561-568 2003
土田隆樹, 島崎智恵美, 幡野健, 松岡浩司, 青木良夫, 野平博之, 江角保明, 照沼大陽
Both of a series of new second generation carbosilane dendrimers having a different number of branches (Me(n)G 2-Mesogen, n=1, 2, 3) and a novel carbosilane dendrimer having an increased length of methylene chain from the core to the second generation (Gradient G 2-Mesogen) with terminal cyanobiphenyl mesogens were prepared. The characterization of the dendrimers was carried out by using differential scanning calorimetry (DSC) and optical polarizing microscopy. All the dendrimers showed smectic A phase. The ranges of the smectic A phase and the texture size of Me(n)G 2-Mesogen were increased with increasing the number of branches. The behavior of phase transition temperature and the texture size of Gradient G 2-Mesogen were similar to those of Me(n)G-2 Mesogen.
Preparation of New Carbosilane Dendrimers Having Terminal Methogens and Investigation of Their Liquid Crystal Characteristics, Koubunshi Ronbunshu

A Therapeutic Agent with Oriented Carbohydrates for Treatment of Infections by Shiga Toxin-producing Escherichia Coli O157:H7
National Academy of Sciences,Proc. Natl. Acad. Sci. USA,99(11):7669-7674 2002
K. Nishikawa, K. Matsuoka, E. Kita, N. Okabe, M. Mizuguchi, K. Hino, S. Miyazawa, C. Yamasaki, J. Aoki, S. Takashima, Y. Yamakawa, M. Nishijima, D. Terunuma, H. Kuzuhara, and Y. Natori

E3 Ubiquitin Ligase that Recognizes Sugar Chains
Nature Publishing Group,Nature,418(6896):438-442 2002
Y. Yoshida, T. Chiba, F. Tokunaga, H. Kawasaki, K. Iwai, T. Suzuki, Y. Ito, K. Matsuoka, M. Yoshida, K. Tanaka, and T. Tai

Improved Solubility of beta-Cyclodextrin Inclusion Complexes by Using Liquid Ammonia as a Solvent and the Possibility of Asymmetric Reduction
Elsevier,Carbohydr. Polym.,47(4):373-376 2002
K. Matsuoka, H. Takahashi, Y. Saito, D. Terunuma, and H. Kuzuhara

An Alternative Route for Constructon of Carbosilane Dendrimers Uniformly Functionalized with Lactose or Sialyllactose Moieties
Elsevier,Tetrahedron Lett.,42(19):3327-3330 2001
K. Matsuoka, H. Oka, T. Koyama, Y. Esumi, and D. Terunuma

Bi-Fluorescence-Labeled Maltoheptaoside: Convenient Substrate for Continual Assay of (alpha)-Amylase
Harwood Academic Publishers,Carbohydr. Lett.,4(2):77-84 2001
S.-I. Nishimura, N. Kimura, K. Matsuoka, and Y. C. Lee
A new maltoheptaose derivative was prepared as a useful substrate for continual assay of alpha-amylase. The maltoheptaoside has thionaphtyl group as a fluorescent energy donor at the reducing end and dansyl group as an acceptor group at the non-reducing end. Excitation of the thionaphthyl group at 290 nm results in emission at 523 nm from the dansyl group, while the emission from the thionaphthyl group is quenched by the dansyl group. This fluorescence energy transfer is reduced by the hydrolytic action with alpha-amylase and a significant decrease in the dansyl emission concomitant with an increase in the thionaphthyl emission was observed. Usefulness of this substrate was demonstrated for sensitive and continuous assay of alpha-amylase from Aspergillus oryzae.

Regioselective Synthesis of Methylated β-Cyclodextrins Leaving Hydroxyl Groups
Elsevier,Tetrahedron Lett.,42(8):1531-1533 2001
K. Matsuoka, Y. Shiraishi, D. Terunuma, and H. Kuzuhara

Synthesis and Reactivity of a 5-Azido Analogue of Neuraminic Acid
Harwood Academic Publishers,Carbohydr. Lett.,4(2):123-130 2001
K. Matsuoka, H. Oka, D. Terunuma, and H. Kuzuhara
A peracetylated phenyl 2-thioglycoside (1) of a 5-azido analogue neuraminic acid methyl ester was prepared from a known 5-amino precursor by a diazo transfer reaction. Glycosidation of 1 by alcohols proceeded smoothly in CH3CN to give alpha-sialylated products in good yield.

An Improved Preparation of N, N'-Diacetylchitobiose by Continuous Enzymatic Degradation of Colloidal Chitin Using Dialysis Tubing as A Convenient Separator
American Chemical Sciety,Biomacromolecules,1(4):798-800 2000
K. Matsuoka, Y. Matsuzawa, K. Kusano, D. Terunuma, and H. Kuzuhara

Synthetic Assembly of Trisaccharide Moieties of Globotriaosyl Ceramide Using Carbosilane Dendrimers as Cores. A New Type of Functional Glyco-Materials
Elsevier,Tetrahedron Lett.,40(44):7839-7842 1999
K. Matsuoka, M. Terabatake, Y. Esumi, D. Terunuma, and H. Kuzuhara

Presentation
Investigation of 2-Benzoylpyridine-Au(III) catalyzed protein conjugation
日本化学会,第98回春季年会 (船橋)講演予稿集 4D3-32 201803
Y. Lin, K. Matsuoka, K. Tanaka

Synthetic studies of polydiacetylenes introducing various carbohydrate moieties at the terminal ends (II): Evaluation of polymerizabilities
日本化学会,第98回春季年会 (船橋)講演予稿集 1D4-11 201803
M. Ishizawa, T. Matsushita, T. Koyama, M. Yasutake, K. Hatano, K. Matsuoka

Synthetic studies of novel functional nanoparticles by means of the reverse micelles method (3) - Preparation and purification of the functional nanoparticles -
日本化学会,第98回春季年会 (船橋)講演予稿集 1D4-12 201803
M. Sakamoto, T. Matsushita, T. Koyama, K. Hatano, K. Matsuoka

Synthesis of gold nanoparticles modified with sugar(III): Investigation of aggregative conditions
日本化学会,第98回春季年会 (船橋)講演予稿集 1D4-17 201803
T. Yonaiyama, T. Matsushita, T. Koyama, K. Hatano, K. Matsuoka

Synthetic study on dissociation mechanism of sialic acid by NA (3): Confirmation and evaluation of the dissociation of p-nitroaniline caused by the cleavage of sialic acid
日本化学会,第98回春季年会 (船橋)講演予稿集 1D4-18 201803
M. Daniel, T. Matsushita, T. Koyama, K. Hatano, K. Matsuoka

Synthetic assembly of sugar moieties using biotin-avidin interaction
Asia Chem Corporation (ACC),International Congress on Pure & Applied Chemistry (ICPAC 2018) (Siem Reap, Cambodia), March 6-10, 2018, OBC 71:139 201803
K. Matsuoka, A. Kumari, T. Koyama, T. Matsushita, K. Hatano

Multivalent-type Bioactive Compounds: Design, Synthesis, and Biological Evaluation
Asia Chem Corporation (ACC),International Symposium on Pure & Applied Chemistry (ISPAC 2017) (Ho Chi Minh City, Vietnam), June 8-10, 2017, BIO 05:213 201706
Koji Matsuoka

Glycocluster: Use of multivalent-type carriers for assembly of carbohydrates
American Chemical Society,ACS 253rd National Meeting (San Francisco, USA), April 2-6, 2017,253:CARB 85 201704
K. Matsuoka

Synthesis of the new class of cellulase substrate by using fluorescence resonance energy transfer (FRET) effect (Ⅶ) ~Synthetic assembly of the substrate monomer~
日本化学会 ,第95回春季年会 (津田沼)講演予稿集,95:4J5-11 201503
K. Kimura, T. Tetsuka, T. Koyama, K. Hatano, K. Matsuoka

Synthesis of biotin-sugar conjugate as an attractive bioprobe : characterization, and their interaction with bio-functional material. (IV)
日本化学会,第95回春季年会 (津田沼)講演予稿集,95:4J5-09 201503
A. Kumari, T. Koyama, K. Hatano, K. Matsuoka

Synthesis of Sugar-Au composite nanoparticles on the basis of sugar cluster effect (IV) ~Biological evalution of the nanoparticles on sugar cluster effect~
日本化学会,第95回春季年会 (津田沼)講演予稿集,95:2J8-53 201503
T. Sakamoto, T. Koyama, K. Hatano, K. Matsuoka

Synthesis of the water soluble glyco-conjugate porphyrin polymer (III) ~Biological evaluations of the porphyrin polymer~
日本化学会,第95回春季年会 (津田沼)講演予稿集,95:1B2-06 201503
M. Ando, T. Koyama, M. Suzuki, Y. Ishimaru, K. Hatano, K. Matsuoka

Synthetic study of the polymer as multivalent bioprobe (III) ~Biological evaluations of the polymeric bioprobes
日本化学会,第95回春季年会 (津田沼)講演予稿集,95:1B2-05 201503
R. Hayama, T. Koyama, K. Hatano, K Matsuoka

Synthesis of Fluorinated Polymers
,The fifth International Symposium on Fluorous Technologies 2013 (ISoFT'13), (Budapest, Hungary), June 2-5, 2013:P9 201306
T. Kimura, M. C. Z. Kasuya, K. Matsuoka, and K. Hatanaka

Probing Single-Molecule Enzymatic Dynamics of β-Glucosidase using Zero-mode Waveguides
Biophysical Society,BIOPHYSICAL JOURNAL [57th Annual Meeting (Philadelphia, USA), February 2-6, 2013],104(2-1):178A (#913-Pos) 201302
R. Iizuka, I. Toshimitsu, K. Tahara, H. Arai, T. Tetsuka, K. Matsuoka, S. Ryu, Y. Asano, T. Tanii, K. Igarashi, M. Samejima, and T. Funatsu

Design, Synthesis, and Biological Evaluation of Glyco-Materials
Biyani Group of Colleges,7th Biyani’s conference (BICON-2012) (Jaipur, India) 201209
K. Matsuoka

Regioselective glycosilation of 2,3,4-trioles of mannoside and galactoside acceptors
,10th International Conference on Heteroatom Chemistry (ICHAC-10), (Kyoto, Japan), May 20 – 25 201205
R. Konose, N. Takahata, K. Matsuoka, and Ken Hatano

Synthesis of carbosilane dendrimer periphery functionalized peptide binding to influenza virus
,10th International Conference on Heteroatom Chemistry (ICHAC-10), (Kyoto, Japan), May 20 – 25 201205
K. Ezure, T. Koyama, K. Matsuoka, T. Matsubara, T. Sato, and Ken Hatano

Synthesis of Sialic Acid Derivatives having a Hydrophobic Chain at the Anomeric Position and C=C Double Bond Substituted at the C-5 Position
2010環太平洋国際化学会議,The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010) (Hawaii, USA):#297 201012
K. Suzuki, T. Koyama, S. Yingsakmongkon, Y. Suzuki, K. Hatano, and K. Matsuoka

Application of Bulky Silyl Protecting Groups for Oligosaccharide Synthesis
2010環太平洋国際化学会議,The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010) (Hawaii, USA):#1676 201012
N. Takahata, T. Koyama, K. Matsuoka, D. Terunuma, and K. Hatano

Application to Drug Derivery System of Carbosilane Dendrimer having Periphery Lactose
2010環太平洋国際化学会議,The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010) (Hawaii, USA):#1680 201012
K. Otomo, N. Honsyo, H. Aizawa, M. Villeneuve, D. Terunuma, K. Matsuoka, and K. Hatano

Synthesis and Investigation of Inhibition Photo-degradation of a Novel Polysilane with Silole Group in the Side Chain
2010環太平洋国際化学会議,The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010) (Hawaii, USA):#1717 201012
Y. Isobe, S. Kamibayashi, K. Matsuoka, D. Terunuma, T. Fukuda, N. Kamata, and K. Hatano

Preparation and Application of Silole Derivatives for Electric Materials
2010環太平洋国際化学会議,The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010) (Hawaii, USA):#1718 201012
K. Mori, R. Kobayashi, T. Fukuda, T. Koyama, N. Kamata, K. Matsuoka, and D. Terunuma, K. Hatano

Syntheses and Biological Evaluations of Novel Glycopolymers bearing S-linked sialyl α(2→6) Galactose Derivatives as Inhibitors for Influenza Neuraminidases
International Carbohydrate Organization,25th International Carbohydrate Symposium (ICS 2010) (Makuhari, Japan),25:184 (A-P2-035) 201008
T. Tsuchibuchi, T. Koyama, N. Sriwilaijaroen, Y. Suzuki, K. Hatano, and K. Matsuoka

Cellular Glycosylation Efficacy of Lactoside Primers Decreases with Increasing Passage Number
International Carbohydrate Organization,25th International Carbohydrate Symposium (ICS 2010) (Makuhari, Japan),25:614 (E-P2-007) 201008
Y. Shimura, M.C. Kasuya, K. Matsuoka, T. Sato, and K. Hatanaka

Mass Preparation of Various Oligosaccharides by COS-7 Cells using Saccharide Primer
International Carbohydrate Organization,25th International Carbohydrate Symposium (ICS 2010) (Makuhari, Japan),25:639 (E-P2-032) 201008
J. Suzuki, Y. Shimura, K. Matsuoka, T. Sato, and K. Hatanaka

Synthesis of Sialic Acid Derivertives having C=C Double Bond Substituted at C-5 Position and Their Influenza Virus Inhibitory Activities
International Carbohydrate Organization,25th International Carbohydrate Symposium (ICS 2010) (Makuhari, Japan),25:179 (A-P3--30) 201008
K. Suzuki, T. Koyama, S. Yingsakmongkon, Y. Suzuki, K. Hatano, and K. Matsuoka

Label-free Glycan Biosensor Based on Localized Surface Plasmon Resonance
International Carbohydrate Organization,25th International Carbohydrate Symposium (ICS 2010) (Makuhari, Japan),25:643 (E-P3-036) 201008
J. Kobayashi, M. Ogiso, M. Itoh, T. Imamura, T. Okada, K. Matsuoka, H. Miura, T. Matsuda, T. Hirahashi, S. Fujieda, S. Yamamoto, T. Mori, Y. Shimura, S. Adachi, J. Suzuki, N. Minoura, and K. Hatanaka

An Application of Carbosilane Dendrimer having Periphery Lactose to A New Smart Drug Delivery Carrier
International Carbohydrate Organization,25th International Carbohydrate Symposium (ICS 2010) (Makuhari, Japan),25:665 (E-P3-061) 201008
H. Aizawa, K. Otomo, N. Honsho, K. Hatano, M. Villeneuve, K. Matsuoka, and D. Terunuma

Synthetic Studies of Bi-fluorescence-labeled Maltooligosaccharides for α-Amylase Assay Based on Fluorescence Resonance Energy Transfer (FRET)
International Carbohydrate Organization,25th International Carbohydrate Symposium (ICS 2010) (Makuhari, Japan),25:162 (A-P5-012) 201008
H. Oka, T. Koyama, K. Hatano, D. Terunuma, and K. Matsuoka

Fabrication of Glycan Biosensor Based on Localized Surface Plasmon Resonance
International Carbohydrate Organization,25th International Carbohydrate Symposium (ICS 2010) (Makuhari, Japan),25:616 (E-P5-009) 201008
M. Ogiso, J. Kobayashi, M. Itoh, T. Imamura, T. Okada, K. Matsuoka, H. Miura, T. Matsuda, T. Hirahashi, S. Fujieda, N. Minoura, and K. Hatanaka

Trivalent-type Substrate having Lex Determinants Available for Determining the Binding Specificity of Lectin
International Carbohydrate Organization,25th International Carbohydrate Symposium (ICS 2010) (Makuhari, Japan),25:629 (E-P5-022) 201008
K. Matsuoka, Y. Yamaguchi, T. Koyama, S. Yamamoto, T. Mori, and K. Hatanaka

シラボリン誘導体の合成
日本化学会,第90回春季年会(東大阪)講演予稿集:3PA-027 201003
池上真人、幡野健、小山哲夫、松岡浩司、照沼大陽

TMG-キトトリオマイシン関連糖鎖の合成研究
日本化学会,第90回春季年会(東大阪)講演予稿集:3PC-017 201003
北村裕二郎、松岡浩司、越野広雪、高橋俊哉

シロールをコアとした糖鎖担持カルボシランデンドリマーの合成とその光学特性の評価
日本化学会,第90回春季年会(東大阪)講演予稿集:3PA-026 201003
幡野健、森祥太、佐伯整、小山哲夫、松岡浩司、照沼大陽

シロール基含有ポリシランの合成及びその発光特性に関する研究
日本化学会,第90回春季年会(東大阪)講演予稿集:2PB-190 201003
上林哲、幡野健、松岡浩司、福田武司、鎌田憲彦、照沼大陽

シロールをコアとした糖鎖担持カルボシランデンドリマーを用いたバイオセンサーへの応用
日本化学会,第90回春季年会(東大阪)講演予稿集:2D4-29 201003
佐伯整、幡野健、相澤宏明、横田洋大、小山哲夫、松岡浩司、照沼大陽

糖鎖担持ポリシロキサンの合成
日本化学会,第90回春季年会(東大阪)講演予稿集:1D4-34 201003
保科有佑、幡野健、小山哲夫、松岡浩司、照沼大陽

シロールをコアとした糖鎖担持カルボシランデンドリマーによるレクチン検出評価
日本化学会,第90回春季年会(東大阪)講演予稿集:1D4-35 201003
森祥太、幡野健、佐伯整、小山哲夫、松岡浩司、照沼大陽

アラビノガラクタン-プロテイン糖鎖の酵素分解と構造解析
日本植物生理学会,第51回年会(熊本)講演要旨集:364 (3pH14) 201003
岡部耕平、下田良平、小竹敬久、松岡浩司、小山哲夫、Paul Dupree、円谷陽一

糖鎖担持デンドリマーの分子包摂能と選択的包摂分子放出能評価
有機合成化学協会,第58回有機合成化学協会関東支部シンポジウム-新潟(長岡)シンポジウム-講演予稿集:E28 200911
相澤宏明、本庄寿壮、大友健太朗、幡野健、松岡浩司、照沼大陽

フコシルキトビオースと糖含有ポリマーの合成研究
東京糖鎖研究会,GlycoTOKYO2009 Symposium (お茶の水)講演要旨集:46 (P28) 200911
山口大希、小山哲夫、幡野健、照沼大陽、松岡浩司

ノイラミニダーゼ阻害剤を指向した糖鎖ポリマーの合成研究
東京糖鎖研究会,GlycoTOKYO2009 Symposium (お茶の水)講演要旨集:37 (P19) 200911
土渕晃司、坂本純一、小山哲夫、幡野健、照沼大陽、松岡浩司

糖鎖を高密度に集積したナノ微粒子の合成
高分子学会,第58回年高分子討論会 (熊本)講演予稿集,58:4957 (2Pf156) 200909
小山哲夫、幡野健、照沼大陽、松岡浩司

フコシルキトビオースを含む糖鎖高分子の合成研究
高分子学会,第58回年高分子討論会 (熊本)講演予稿集,58:4955 (2Pf154) 200909
山口大希、小山哲夫、幡野健、照沼大陽、松岡浩司

表面に機能性糖鎖を有する磁性体微粒子の調製と評価
日本化学会,第3回関東支部大会 (早稲田)講演予稿集:118 (P2-028) 200909
吉野孝司、小山哲夫、幡野健、松岡浩司、照沼大陽

シリカ微粒子の表面修飾による粒子配列の調整
日本化学会,第3回関東支部大会 (早稲田)講演予稿集:111 (P1-073) 200909
武居裕樹、幡野健、松岡浩司、照沼大陽

シロール誘導体のポリマー化とその薄膜評価
日本化学会,第3回関東支部大会 (早稲田)講演予稿集:113 (P2-007) 200909
島崎知之、石田慶介、幡野健、松岡浩司、福田武司、鎌田憲彦、照沼大陽

シロール基を有するポリシランの合成及びその発光特性に関する研究
日本化学会,第3回関東支部大会 (早稲田)講演予稿集:128 (P2-064) 200909
上林哲、幡野健、松岡浩司、福田武司、鎌田憲彦、照沼大陽

シロール含有糖鎖担持カルボシランデンドリマーの水/アセトン混合溶媒中の蛍光強度変化と粒子状体の挙動
日本化学会,第3回関東支部大会 (早稲田)講演予稿集:13 (1A2-23) 200909
相澤宏明、本庄寿壮、幡野健、松岡浩司、照沼大陽

2,5-位にアルキル基を有する新規シロール誘導体の合成と蛍光挙動
日本化学会,第3回関東支部大会 (早稲田)講演予稿集:142 (P3-034) 200909
鈴木悠、幡野健、松岡浩司、福田武司、鎌田憲彦、照沼大陽

一段階法による糖鎖を表面に有するシリカ微粒子の合成
日本化学会,第3回関東支部大会 (早稲田)講演予稿集:119 (P2-029) 200909
高玉智史、大山直人、小山哲夫、幡野健、松岡浩司、照沼大陽

インフルエンザ阻害剤を指向したシアリルラクトサミン糖鎖クラスターの化学 酵素合成
日本化学会,第3回関東支部大会 (早稲田)講演予稿集:121 (P2-039) 200909
馬暁涛、小山哲夫、幡野健、照沼大陽、松岡浩司

多価型ノイラミニダーゼ阻害剤の合成研究
日本化学会,第3回関東支部大会 (早稲田)講演予稿集:118 (P2-027) 200909
土渕晃司、坂本純一、小山哲夫、幡野健、照沼大陽、松岡浩司

新規シアル酸誘導体の合成とインフルエンザウイルス阻害活性
日本化学会,第3回関東支部大会 (早稲田)講演予稿集:45 (1A7-08) 200909
鈴木香識、坂本純一、小山哲夫、鈴木康夫、幡野健、照沼大陽、松岡浩司

Dumbbell(1)6の溶液中における構造評価
日本化学会,第3回関東支部大会 (早稲田)講演予稿集:143 (P3-040) 200909
本庄寿壮、相澤宏明、三原宇史、ヴィレヌーブ真澄美、幡野健、松岡浩司、照沼大陽

多価型化合物を標的とした合成研究
第3回医薬品原料国際展,第3回医薬品原料国際展 (ファーマ i ジャパン) 200907
松岡浩司、幡野健、照沼大陽
東京ビックサイト

シアリルα(2→6)ラクトース誘導体の合成と抗インフルエンザウィルス活性評価
繊維学会,平成21年度年次大会 (船堀)講演予稿集:205 (2F07) 200906
松岡浩司、白子文隆、小山哲夫、幡野健、照沼大陽、Nongluk Sriwilaijaroen、Sangchai Yingsakmongkon、鈴木康夫

Highly luminescent glycocluster in organic solvent: silole-core carbosilane dendrimer having peripheral globotriaose
Post ISOS XV Symposium,Post ISOS XV Symposium (Gunma, Japan):P-1 200806
H. Aizawa, H. Yokota, A Yamada, T. Koyama, K. Hatano, K. Matsuoka, and D. Terunuma

Syntheses and Photoluminescence of Silole Core Carbosilane Dendrimers Peripheral Functionalize with Carbohydrates
Post ISOS XV Symposium,Post ISOS XV Symposium (Gunma, Japan):P-28 200806
H. Saeki, K. Hatano, H. Yokota, H. Aizawa, T. Koyama, K. Matsuoka, and D. Terunuma

Synthesis and Lectin-binding Activities of Carbohydrate-modified Polysiloxanes
Post ISOS XV Symposium,Post ISOS XV Symposium (Gunma, Japan):P-58 200806
Y. Hoshina, K. Hatano, T. Koyama, K. Matsuoka, and D. Terunuma

Synthesis of Carbosilane Dendrimers Having Sialyl Lactosamine as an Influenza Virus Inhibitor
The First Asian Silicon Symposium and The 12th Symposium of the Society of Silicon Chemistry,The First Asian Silicon Symposium and The 12th Symposium of the Society of Silicon Chemistry (Miyagi, Japan):P017 200711
Y. Hirai, A. Yamada, T. Koyama, K. Hatano, K. Matsuoka, Y. Suzuki, and D. Terunuma

Synthesis and Characterization of Silica Particles Surface-modified by Functional Saccharides
The First Asian Silicon Symposium and The 12th Symposium of the Society of Silicon Chemistry,The First Asian Silicon Symposium and The 12th Symposium of the Society of Silicon Chemistry (Miyagi, Japan):P108 200711
T. Yamazaki, K. Hatano, N. Oyama, K. Matsuoka, N. Kamata, and D. Terunuma

Synthesis and Evaluation of Silole-containing Carbosilane dendrimers Bearing Carbohydrates
The First Asian Silicon Symposium and The 12th Symposium of the Society of Silicon Chemistry,The First Asian Silicon Symposium and The 12th Symposium of the Society of Silicon Chemistry (Miyagi, Japan):P110 200711
H. Yokota, K. Hatano, A. Yamada, T. Koyama, K. Matsuoka, and Daiyo Terunuma

Design, Synthesis, and Biological Evaluation of Glyco-Materials
International Organization on Biotechnology, Metal complexes and Catalysis,8th International Symposium on Biotechnology, Metal complexes and Catalysis (BMC-VIII):IL-BT-05 200611
K. Matsuoka

Effect of synthetic carbohydrate derivatives on dengue virus infection
International Consortium on Anti-Virals,4th Symposium and First pacific Rim Meeting of The International Consortium on Anti-Virals (Gold Coast, Australia) Abstracts:8 200609
K. I.-P. J. Hidari, N. Takahashi, C. Aoki, A. Yamada, K. Hatano, K. Matsuoka, D. Terunuma, F. Hasebe, K. Morita, Y. Suzuki, and T. Suzuki

Thiosialoside Clusters as Inhibitors for Influenza Virus Neuraminidases
International Committee on the Organic Chemistry of Sulfur,22nd International Symposium on the Organic Chemistry of Sulfur (ISOCS-22):P-105 200608
J.-I. Sakamoto, C. Takita, T. Koyama, K. Hatano, D. Terunuma, Y. Esumi, K. I.-P. J. Hidari, S. Yingsakmongkon, D. Miyamoto, W. Usawattanakul, T. Suzuki, Y. Suzuki, and K. Matsuoka

Synthesis of a Series of Carbosilane Dendrimers Having Thioglycoside-type Sialic Acid Moieties
International Carbohydrate Organization,XXIIIrd International Carbohydrate Symposium (ICS2006):THU-PS.37 200607
J.-I. Sakamoto, T. Koyama, Y. Esumi, H. Koshino, K. I.-P. J. Hidari, T. Suzuki, Y. Suzuki, K. Hatano, D. Terunuma, and K. Matsuoka

Synthetic Construction of Novel Sugar―Amino Acid Hybrid Materials Using Typical Radical Polymerization Protocol
International Carbohydrate Organization,XXIIIrd International Carbohydrate Symposium (ICS2006):THU-PS.28 200607
K. Matsuoka, Y. Goshu, T. Koyama, K. Hatano, and D. Terunuma

Identification and characterization of carbohydrate determinant that is recognized with domain III of dengue virus envelope glycoprotein
IUBMB International Congress of Biochemistry and Molecular Biology and FAOBMB Congress,20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress (Kyoto, Japan), Abstracts:120 200606
K. I.-P. J. Hidari, C. Aoki, A. Yamada, F. Hasebe, M. A. Islam, K. Hatano, K. Matsuoka, C.-T. Guo, T. Takahashi, Y. Sakano, T. Suzuki, D. Miyamoto, D. Terunuma, K. Morita, and Y. Suzuki

Synthesis and optical properties of silyl-substituted pyrenes
2005環太平洋国際化学会議,PACIFICHEM 2005 (Hawaii, USA), Abstract:4646 200512
N. Ohyama, K. Hatano, K. Matsuoka, N. Kamata, D. Terunuma

Synthesis and property of 1,4-disilabicyclo[2.2.2]octane
2005環太平洋国際化学会議,PACIFICHEM 2005 (Hawaii, USA), Abstract:4644 200512
H. Aizawa, K. Hatano, K. Matsuoka, N. Kamata, and D. Terunuma

Synthesis and characterization of new soluble polydiphenylsilane co-polymers
2005環太平洋国際化学会議,PACIFICHEM 2005 (Hawaii, USA), Abstract:5817 200512
T. Sato, K. Hatano, N. Kamata, K. Matsuoka, and D. Terunuma

Synthesis of linear permethyl oligosilanes with liquid crystalline molecules
2005環太平洋国際化学会議,PACIFICHEM 2005 (Hawaii, USA), Abstract:5816 200512
T. Nakano, K. Hatano, Y. Aoki, K. Matsuoka, N. Kamata, and D. Terunuma

Inhibition of shiga toxin adhesion by carbosilane dendrimer periphery functionalized bioactive sugar
2005環太平洋国際化学会議,PACIFICHEM 2005 (Hawaii, USA), Abstract:1866 200512
A. Yamada, K. Hatano, K. Matsuoka, Y. Esumi, K. Hino, K. Nishikawa, Y. Natori, and D. Terunuma

Syntheses and biological properties of a series of lacto-N-neotetraose cluster using carbosilane dendrimer scaffolds
2005環太平洋国際化学会議,PACIFICHEM 2005 (Hawaii, USA), Abstract:1865 200512
A. Yamada, K. Hatano, K. Matsuoka, Y. Esumi, C. Aoki, K. Hidari, Y. Suzuki, and D. Terunuma

Syntheses and characterization of new polysilanes bearing pendant liquid-crystalline molecules
2005環太平洋国際化学会議,PACIFICHEM 2005 (Hawaii, USA), Abstract:5455 200512
H. Takahashi, K. Hatano, Y. Aoki, K. Matsuoka, N. Kamata, and D. Terunuma

Advantages of Carbosilane Dendrimer as a Carbohydrate Scaffold -Application to Artificial Receptor of E. Coli, Influenza and Dengue Virus-
The 14th International Symposium on Organosilicon Chemistry (ISOS-XIV),The 14th International Symposium on Organosilicon Chemistry (ISOS-XIV) Abstract:78 200508
Ken Hatano, Akihiro Yamada, Tetsuo Koyama, Koji Matsuoka, Daiyo Terunuma, Yasuaki Esumi, Kiyotaka Nishikawa, Yasuhiro Natori, Kazuya Hidari, and Yasuo Suzuki

Syntheses and Biological Assay of a Series of Lacto-N-neotetraose Cluster using Carbosilane Dendrimer Scaffolds
The 14th International Symposium on Organosilicon Chemistry (ISOS-XIV),The 14th International Symposium on Organosilicon Chemistry (ISOS-XIV) Abstract:134 200508
Akihiro, Yamada, Ken Hatano, Koji Matsuoka, Yasuaki Esumi, Chie Aoki, Kazuya Hidari, Yasuo Suzuki and Daiyo Terunuma

Synthesis and Biological Evaluation of Glycopolymer as Shiga toxin Neutralizar
US/JAPAN GLYCO2004, Joint Meeting of the Society for Glycobiology and the Japanese Society of Carbohydrate Research,Glycobiology,14:1194 200411
K.Matsuoka, A.Miyagawa, K.Nishikawa, M.Watanabe, Y.Natori, E.Kita, T.koyama, K.Hatano, D.Terunuma

Synthesis and Property of Carbosilane Dendrimers Functionalizing Peripheral Mannose Moieties
US/JAPAN GLYCO2004, Joint Meeting of the Society for Glycobiology and the Japanese Society of Carbohydrate Research,Glycobiology,14:1093 200411
T. Mori, K. Hatano, K. Matsuoka, Y. Esumi, E. J. Toone, and D. Terunuma

Patents

Patents
糖鎖含有カルボシランデンドリマー化合物とその製造方法並びにベロ毒素中和剤と抗ウイルス剤 , Sugar Chain-Containing Carbosilane Dendrimer Compounds, Method for Producting the Same, Verotoxin Neutralizers and Antivaral Agents, WO02/002588
Saccharide residue-functional organopolycarbosiloxanes and method for the preparation thereof
Saccharide residue-functional organopolysiloxanes and method for the preparation thereof
SUGAR-MODIFIED PARTICLE AND METHOD FOR PRODUCTION THEREOF
病原性微粒子吸着性中空糸及び病原性微粒子除去装置
糖残基を有するオルガノポリカルボシロキサンおよびその製造方法
糖残基を有するオルガノポリシロキサンおよびその製造方法
アミド結合型糖鎖含有カルボシランデンドリマーおよびその製造方法
新規ラクトサミン誘導体とその製造方法
糖鎖含有カルボシランデンドリマー化合物とその製造方法並びにベロ毒素中和剤と抗ウィルス剤
ガラビオース結合カルボシランデンドリマー化合物
新規シアル酸供与体とその製造方法並びにそれを用いたシアル酸の導入方法
ベロ毒素中和剤
新規糖鎖担持カルボシランデンドリマーおよびその製造方法、並びにデング熱ウィルス感染阻害剤、抗ウィルス財及び抗HIV剤のスクリーニング用標的物質
シアリルラクトサミン担持デンドリマー化合物
チオグリコシド型シアル酸結合デンドリマー化合物
シアル酸チオグリコシドポリマー
チオシアロシド型オリゴ糖を含む糖鎖デンドリマーの製造方法及びその利用
シアリル a(2-6)ラクトース含有化合物及びその利用
シアル酸誘導体の製造方法とインフルエンザウィルス阻害剤としての利用
蛍光性アミラーゼ基質及び該基質を用いたアミラーゼ活性測定方法
ウィルス、微生物等の検出方法
フコシルキトビオース誘導体の製造方法
糖鎖担持デンドリマーからなる標的選択的薬剤放出担体
発光の色調変化による複数微生物の同時検出方法
FRETを利用した酵素活性測定基質及びその製造方法
金含有物への糖鎖の導入法
ダブルビオチンアンカー型リガンド固定化分子

Themes for Joint Research

Verotxin, Carbosilane dendrimers, Globotriaose, Glycopolymers , Synthetic chemistry, Polymer chemistry, Medicinal chemistry , Verotoxin neutralizer
Influenza viruses, Carbosilane dendrimers, Inhibitors, Glycopolymers , Synthetic chemistry, Polymer chemistry, Virology, Medicinal chemistry , Anti-influenza virus drugs
Cyclodextrin, Asymmetric synthesis, Methylation , Organic chemistry, Supramolecular chemistry, Synthetic chemistry , Development of functional materials based on cyclodextrins

Education

Lectures

2011 , 1st Semester , Organic Advanced Materials
2008 , 1st Semester , Introduction to Functional Materials Science
2008 , 2nd Semester , Organic Chemistry of Materials
2008 , 1st Semester , Polymer Science
2008 , 1st Semester , Exercises in Foundation of Functional Materials Science I
2008 , 2nd Semester , Exercises in Foundation of Functional Materials Science II
2008 , 2nd Semester , Experiments in Functional Materials Science III
2008 , 2nd Semester , Synthetic Studies of Functional Molecules
2008 , 2nd Semester , Chemistry of Glycoconjugates
2008 , 2nd Semester , Ecomaterial Science

Admission of International Students

2014 , Second Term:2 , Kazakhstan & Mexico

Admission of Researchers

2016-2017 , Synthetic studies of novel Stx neutralizer
2015-2016 , 感染症及びがんの早期検出薬・診断薬の研究開発